Imikhiqizo

I-Ivermectin (i-Cardomec, i-Eqvalan, i-Ivomec) iyingxube ye-22,23-dihydro derivatives ye-avermectins B1a ne-B1b elungiswe yi-catalytic hydrogenation.Ama-Avermectin angamalungu omndeni wemithi elwa namagciwane enesakhiwo eyinkimbinkimbi ekhiqizwa ukuvutshelwa ngohlobo lwe-Streptomycesavermitilis.Ukutholwa kwabo kwaba umphumela wokuhlolwa okujulile kwamasiko ama-anthelmintic agents avela emithonjeni yemvelo.I-Ivermectin iyasebenza ngethamo eliphansi ngokumelene nezinhlobonhlobo zama-nematode nama-arthropods ama-parasitizeanimals.
Ivermectin uye wazuza ukusetshenziswa kabanzi in veterinarypractice e-United States kanye namazwe amaningi emhlabeni wonke ukulawula endoparasites kanye ectoparasitesin izilwane ezifuywayo.Kutholwe kusebenza ngempumelelo ekwelapheni i-onchocerciasis (“ubumpumputhe bomfula”) kubantu, isifo esibalulekile esibangelwa i-roundwormOncocerca volvulus, evame kakhulu eNtshonalanga ne-Afrika Ephakathi, eMpumalanga Ephakathi, naseNingizimu neMelika Ephakathi. izinhlobo ze-nematode, ezidala izigaxa zesikhumba nezicubu eziwuphawu lokuhlasela futhi ezingaholela ebumpumputheni. Iphinde ivimbele ukukhululwa kwe-microfilariae yizibungu zabantu abadala ezihlala endaweni.Ucwaningo ngendlela yesenzo se-ivermectin lubonisa ukuthi ivimba ukudluliselwa kwe-interneuron-motor neuron kumanematode ngokugqugquzela ukukhululwa kwe-GABA ye-neurotransmitter evimbelayo.Umuthi wenziwa watholakala ngumkhiqizi ngesisekelo sosizo ezinhlelweni zokwelashwa eziqeqeshiwe nge-World Health Organization.

I-Ivermectin inomsebenzi we-spectrum ebanzi ngoba ingathinta ama-nematodes, izinambuzane, nama-acarine parasites.Kuwumuthi okhethwayo ku-onchocerciasis futhi uwusizo kakhulu ekwelapheni ezinye izinhlobo ze-filariasis, i-strongyloidiasis, i-ascariasis, i-loiasis, kanye nezibungu ezifudukayo.Iphinde isebenze kakhulu ngokumelene nezibungu ezihlukahlukene.Kuwumuthi okhethwayo ekwelapheni abantu abangenwe yi-Onchocerca volvulus, esebenza njengesidakamizwa esincane esilwa nezibungu ezihlala esikhumbeni (microfilaria).Ukwelashwa kwaminyaka yonke kungavimbela ubumpumputhe ku-ochocerciasis yamehlo.I-Ivermectin iphumelela kakhulu kune-diethylcarbamazine ku-bancroftian filariasis, futhi yehlisa i-microfilaremia ifinyelele kumazinga acishe abe nguziro.Ku-brugian filariasis, imvume eyenziwe yi-diethylcarbamazine ingaba ngcono.Ibuye isetshenziselwe ukwelapha izibungu ezifudukayo zesikhumba kanye ne-strongyloidiasis esakazwayo.Ukusetshenziswa kwayo okuphephile ekukhulelwe akukasungulwa ngokugcwele.