Ebukhoneni be-glucose engu-2.8 mM D-glucose, i-beta-D-glucose pentaacetate (1. 7 mM) ikhulise ukukhululwa kwe-insulin eziqhingini ze-pancreatic zegundane elihlukanisiwe ngaphezu kwe-alpha-D-glucose pentaacetate.Ngokufanayo, ukwanda okwengeziwe kokukhishwa kwe-insulin okudalwe yi-nateglinide (0.01 mM) kwakuphakeme eziqhingini ezivezwe ku-beta- kune-alpha-D-glucose pentaacetate.Ngokuphambene, lapho kukhona i-D-glucose engaqinisekisiwe engu-2.8 mM, i-alpha-L-glucose pentaacetate, kodwa hhayi i-beta-L-glucose pentaacetate, ukukhishwa kwe-insulin okuthuthuke kakhulu.Amandla aphezulu e-insulinotropic we-beta-anomer ye-D-glucose pentaacetate aqondane nokuthi inyuse kakhulu isilinganiso esibhanqiwe phakathi kwe-D-[U-14C]glucose oxidation kanye no-D-[5-3H] ukusetshenziswa kweglucose, kuyilapho i-alpha-D -i-glucose pentaacetate yehlulekile ukwenza lokho.Lokhu okutholakele kuhunyushwa ukuze kusekele umqondo wokuthi ukugqugquzelwa kokukhishwa kwe-insulin yilawa ma-ester kubangelwa kakhulu ukusebenzisana kwawo okuqondile ne-stereospecific receptor, ngokuncamela ukumiswa kwe-C1 evamile ku-beta-D-glucose pentaacetate kanye ne-alpha-L- i-glucose pentaacetate.
