I-Guanosine-5'-diphosphate, usawoti we-disodium Cas: 7415-69-2 Impushana emhlophe 98%
| Inombolo Yekhathalogi | XD90756 |
| Igama Lomkhiqizo | I-Guanosine-5'-diphosphate, usawoti we-disodium |
| I-CAS | 7415-69-2 |
| I-Molecular Formula | I-C10H13N5Na2O11P2 |
| Isisindo samangqamuzana | 487.16 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| Isivivinyo | >99% |
| Amanzi | <10% |
I-RasGrf1 ne-RasGrf2 yizici zokushintshana kwe-mammalian guanine nucleotide ezikwazi ukwenza kusebenze ama-Ras noma ama-Rho GTPase athile.Izakhi zofuzo ze-RasGrf zivezwa ngokukhethekile ohlelweni lwezinzwa olumaphakathi, nakuba inkulumo ethize yanoma iyiphi i-locus ingase yenzeke kwenye indawo.I-RasGrf1 iwufuzo oluvezwe nguyise, olugxiviziwe oluvezwa kuphela ngemva kokuzalwa.Ngokuphambene, i-RasGrf2 ayiphrintiwe futhi ibonisa iphethini yokuveza ebanzi.Izinhlobonhlobo zama-isoform azo zombili izakhi zofuzo nazo ziyabonakala ezimeni ezahlukene zamaselula.Amaprotheni e-RasGrf abonisa izakhiwo ze-modular ezakhiwe izizinda eziningi ezihlanganisa i-CDC25H ne-DHPH motifs enesibopho sokuphromotha ukushintshana kwe-GDP/GTP, ngokulandelanayo, kokuhlosiwe kwe-Ras noma i-Rho GTPase.Izizinda ezahlukahlukene zibalulekile ukuze kuchazwe umsebenzi wazo wokushintshisana wangaphakathi kanye nokulinganisa ukucaciswa komsebenzi wazo osebenzayo ukuze kuxhunywe amasiginali ahlukene omfula ezindaweni ezihlosiwe ezihlukene zomfula kanye nezimpendulo zamaselula.Ngaphandle kwe-homology yazo, i-RasGrf1 ne-RasGrf2 zibonisa ukucaciswa okuhlukile okuhlosiwe kanye nezindima zokusebenza ezingagqoki ezimongweni ezihlukahlukene zokusayina ezihlobene nokukhula kweseli nokuhlukaniswa kanye nokuthakasela kwe-neuronal nokusabela noma i-synaptic plasticity.Nakuba womabili ama-RasGrfs esebenza ngama-glutamate receptors, ama-G-protein-coupled receptors noma izinguquko ekugxilweni kwe-calcium ye-intracellular, i-RasGrf1 kuphela okubikwa ukuthi yenziwe i-LPA, i-cAMP, noma i-Trk ecushwe yi-agonist kanye nama-cannabinoid receptors.Ukuhlaziywa kwezinhlobo ezihlukahlukene zamagundane angqongqozayo kwembule umnikelo othile osebenzayo we-RasGrf1 ezinqubweni zenkumbulo nokufunda, ukwamukela izithombe, ukulawulwa kokukhula kwangemva kokubeletha nosayizi womzimba kanye nokusebenza kwe-pancreatic β-cell kanye ne-glucose homeostasis.Ku-RasGrf2, izindima ezithile ekwandeni kwe-lymphocyte, izimpendulo zesignali ye-T-cell kanye ne-lymphomagenesis zichaziwe.
