Imikhiqizo

I-histamine H4 receptor (HRH4), etholwe eminyakeni eyi-13 kuphela edlule, ithathwa njengethagethi ethembisayo yomuthi wokungezwani komzimba, ukuvuvukala, ukuphazamiseka kwe-autoimmune nomdlavuza, njengoba kuboniswa inani elikhula kancane lokushicilelwa kwesayensi kanye nezicelo zelungelo lobunikazi.Nakuba ukuba khona kwe-HRH4 kuye kwafakazelwa ku-testis, ukwenziwa kwayo kwendawo ethile noma indima yayo ayikasungulwa.Lapha, besifuna ukuhlonza ukubandakanyeka okungenzeka kwe-HRH4 ekulawuleni ukusebenza kweseli le-Leydig.Siqale sahlola ukusho kwayo kumaseli e-MA-10 Leydig isimila bese sihlola imiphumela yama-agonists amabili e-HRH4 ku-steroidogenesis nokwanda.Sithole ukuthi i-HRH4 isetshenziswa ngokusebenza kumaseli e-MA-10, nokuthi ukusebenza kwayo kuholela ekuvinjweni kokukhiqizwa kwe-cAMP ye-LH/chorionic gonadotropin-induced cAMP kanye ne-Star protein expression.Ngaphezu kwalokho, sibone ukuncipha kokusabalala kwamaseli ngemva kokwelashwa kwe-agonist okungamahora angama-24 e-HRH4.Sibe sesithola amasayithi we-HRH4 expression in the normal rat test tis, futhi sathola i-HRH4 immunostaining kumaseli e-Leydig amagundane aneminyaka engu-7-240 izinsuku, kuyilapho amagundane anezinsuku ezingama-21 ubudala nawo ethule inkulumo ye-HRH4 kuma-gametes wesilisa.Okokugcina, sihlole umthelela wokwenza kusebenze i-HRH4 ekwandeni kokhokho ovamile kanye nesiko leseli legundane elingavuthiwe le-Leydig, futhi kokubili kubonakale kusengozini yomphumela wokulwa nokwanda kwama-agonists e-HRH4.Njengoba kunikezwe ukubaluleka kwe-histamine (2-(1H-imidazol-4-yl) ethanamine) kumuntu (patho) physiology, imizamo eqhubekayo iqondiswe ekucaciseni izici ezivelayo ze-HRH4 kanye nemigqa yayo.Lolu cwaningo luveza amasayithi amasha enkulumo ye-HRH4, futhi kufanele kubhekwe ekwakhiweni kwama-agonists e-HRH4 akhethiwe ngezinjongo zokwelapha.