Iodonitrotetrazolium chloride CAS:146-68-9
| Inombolo Yekhathalogi | XD90473 |
| Igama Lomkhiqizo | Iodonitrotetrazolium chloride |
| I-CAS | 146-68-9 |
| I-Molecular Formula | I-C19H13ClIN5O2 |
| Isisindo samangqamuzana | 505.70 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukuhlonza | H-NMR |
| Ukubukeka | Okuphuzi okukhanyayo kuya kumpushana owolintshi |
| Isivivinyo | >99% |
| Ukuncibilika | Isixazululo esicacile |
I-Interferon-induced transmembrane protein 1 (IFITM1) ingelinye lamalungu omndeni we-interferon-induced transmembrane protein.Kulolu cwaningo, sibike ukuthi inkulumo ephakanyisiwe ye-IFITM1 kumdlavuza we-colorectal womuntu (CRC) ihlotshaniswa kakhulu ne-CRC lymph node kanye ne-metastasis yebanga kanye nesigaba somtholampilo esithuthuke kakhulu.Okubalulekile, isisho esiphakanyisiwe se-IFITM1 siyisici esizimele sokubikezela ukusinda okubi.Ukuze siphenye izindlela zamangqamuzana, sibonise ukuthi ukuvezwa ngokweqile kwe-IFITM1 kumaseli e-CRC kukhuthaziwe, kuyilapho ukugoqa kwenkulumo ye-IFITM1 kuvinjelwe, ukufuduka kweseli/ukuhlasela kanye ne-tumorigenicity in vitro.Ngaphezu kwalokho, sihlonze i-Caveolin-1 (CAV1) njengethagethi engezansi yokuhlasela kweseli eyenziwe yi-IFITM1, njengokushayisana kwe-CAV1 echithiwe i-siIFITM1 ukuvimbela okulamule kokuhlasela kwamaseli kumaseli e-CRC.Ukwengeza, eqenjini le-CRC leziguli ze-229, inkulumo ye-IFITM1 ihlotshaniswa ngokuphambene nenkulumo ye-CAV1.Le miphumela iphakamise ukuthi i-IFITM1 iphromotha ukuqina kwamaseli e-CRC, futhi iwuphawu olunamandla lokubikezela kanye nethagethi yokwelapha ye-CRC.
