I-L-Glutamine Cas: 56-85-9 99% Impushana emhlophe
| Inombolo Yekhathalogi | XD90309 |
| Igama Lomkhiqizo | I-L-Glutamine |
| I-CAS | 56-85-9 |
| I-Molecular Formula | I-C5H10N2O3 |
| Isisindo samangqamuzana | 146.1445 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29241900 |
Ukucaciswa Komkhiqizo
| Izinga Lokushisa Lokugcina | +20 ° C |
| Isisindo samangqamuzana | 146.14 |
| Isivivinyo | 99.0% iminithi |
| Ukubukeka | Impushana emhlophe |
1.I-Early T-cell precursor leukemia (ETP-ALL) iwuhlobo oluncane oluyingozi kakhulu lwe-leukemia yomuntu engaqondakali kahle ezingeni lamangqamuzana.Lapha sibika ukuthutha okuqondise umunwe we-zinc E-box-binding transcription factor ZEB2 njengesilonda sofuzo esiphindelelayo ku-immature/ETP-ALL.Sisebenzisa imodeli yegundane enemibandela, sibonisa ukuthi isisho se-Zeb2 esizinzile siqala i-T-cell leukemia.Ngaphezu kwalokho, i-leukemia yegundane eqhutshwa i-Zeb2 ibonisa izici ezithile zesiginesha yokubonisa isakhi sofuzo esingavuthiwe/ETP-ALL, kanye namandla athuthukisiwe okuqalisa i-leukemia kanye nama-Janus kinase (JAK)/ama-signal transducer acushiwe nama-activator of transcription (STAT) asayinda ukwenziwa kusebenze kokubhalwe phansi kwe-IL7R.Lolu cwaningo luveza i-ZEB2 njenge-oncogene ku-biology ye-immature/ETP-ALL futhi luvula indlela eya ezifundweni zangaphambi komtholampilo zezinhlanganisela zenoveli zokwelashwa kwalolu hlobo oluncane olunolaka lwe-T-ALL yomuntu kusetshenziswa imodeli yethu yegundane eliqhutshwa i-Zeb2.
2.I-Pluripotency, ukuzivuselela, kanye nokuhlukanisa izici ezikhethekile zamaseli e-embryonic stem (ES), ngaleyo ndlela anikeze imibono ebalulekile emithini yokuvuselela.Izinqubo zokuthuthuka zidinga inhlangano ecushwe kahle, ikakhulukazi elawulwa izindlela ezaziwa kakhulu ze-JAK/STAT, PI3K/AKT, kanye ne-ERK/MAPK.Ama-SPRED (Amaprotheni ahlobene ne-Sprouty anesizinda se-EVH1) atholwe njengama-inhibitors endlela yokusayina ye-ERK/MAPK, kuyilapho akukho okwakwaziwa ngemisebenzi yawo kumaseli e-ES nangesikhathi sokuhlukaniswa kwasekuqaleni, kuze kube manje.Sikhiqize i-SPRED1 ne-SPRED2 overexpressing kanye ne-SPRED2 knockout murine ES amaseli ukuhlaziya imisebenzi yamaprotheni e-SPRED kumaseli e-ES nangesikhathi sokuhlukaniswa kokuqala.Ukweqiwa ngokweqile kwama-SPREDs kukhulisa kakhulu ukuzivuselela kanye ne-clonogenicity yamaseli e-murine ES, kanti ukuntuleka kwe-SPRED2 kunciphisa ukwanda futhi kwandisa i-apoptosis.Ngesikhathi sokuhlukaniswa kwangaphambi kwesikhathi emizimbeni ye-embryoid, ama-SPRED athuthukisa isimo se-pluripotent futhi avimbele ukuhlukaniswa lapho ukuhlukaniswa kwe-mesodermal d ku-cardiomyocytes kulibaziseka kakhulu futhi kuvinjelwe.I-LIF- kanye nokukhuthaza ukukhula kwembula ukuthi ama-SPRED avimbela ukusebenza kwe-ERK/MAPK kumaseli e-murine ES.Kodwa-ke, akukho miphumela eyatholakala ekusebenzeni okubangelwa yi-LIF kwe-JAK/STAT3, noma i-PI3K/AKT indlela yokusayina ngamaprotheni e-SPRED. Indlela yokusayina ye-MAPK kumaseli e-pluripotent.
