I-L-Hydroxyproline Cas: 51-35-4 Impushana emhlophe
| Inombolo Yekhathalogi | XD90292 |
| Igama Lomkhiqizo | I-L-Hydroxyproline |
| I-CAS | 51-35-4 |
| I-Molecular Formula | I-C5H9NO3 |
| Isisindo samangqamuzana | 131.13 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 2933998040 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | Impushana emhlophe |
I-Idiopathic pulmonary fibrosis kucatshangwa ukuthi ihilela ukulimala kwamaphaphu okubangelwa uhlobo lwe-oksijini esebenzayo (ROS), okubuye kulandele i-fibrosis engavamile.I-transforming growth factor (TGF) -β1-indeed ukwanda kwenombolo ye-myofibroblast idlala indima ebalulekile kule fibrosis engavamile.Muva nje sithole ukuthi i-mepenzolate bromide (mepenzolate), esetshenziswe emtholampilo ukwelapha ukuphazamiseka kwamathumbu, inezinto zokunciphisa i-ROS.Ocwaningweni lwamanje, sihlole umphumela we-mepenzolate ku-bleomycin-induced pulmonary fibrosis kanye nokungasebenzi kahle kwamaphaphu kumagundane.Ubukhulu be-pulmonary fibrosis buhlolwe ngokuhlolwa kwe-histopathologic kanye nokunqunywa kwamazinga e-hydroxyproline.Imishini yamaphaphu (i-elastance) kanye nomsebenzi wokuphefumula [umthamo obalulekile ophoqelelwe (FVC)] kwahlolwa kusetshenziswa umshini wokungenisa umoya olawulwa ngekhompuyutha.Umsebenzi wokuphefumula uphinde wahlolwa ngokuqapha i-percutaneous arterial oxygen saturation (SpO2).Ukuphathwa kwe-intracheal ye-mepenzolate ngaphambi kokwelashwa kwe-bleomycin kwehlise izinga le-pulmonary fibrosis kanye nezinguquko kumishini yamaphaphu futhi kwaholela ekululameni okuphawulekayo kwakho kokubili i-FVC ne-SpO2 uma kuqhathaniswa nokulawula.Ngaphezu kwalokho, i-mepenzolate yakhiqiza umphumela wokwelapha ngisho nalapho ilawulwa ngemva kokuthuthukiswa kwe-fibrosis.Ukuphathwa kwe-mepenzolate kuphinde kwavimbela ukufa kweseli yamaphaphu okubangelwa i-bleomycin kanye nezimpendulo zokuvuvukala kanye nenombolo ye-myofibroblast eyandayo.I-Mepenzolate iphinde yehlisa umsebenzi we-NADPH oxidase kanye nezinga elisebenzayo le-TGF-β1 noma ukwanda komsebenzi we-glutathione S-transferase (GST) lapho kukhona ukwelashwa kwe-bleomycin.Le miphumela ibonisa ukuthi ukuphathwa kwe-intracheal ye-mepenzolate kwehlise i-bleomycin-induced pulmonary fibrosis kanye nokungasebenzi kahle kwamaphaphu kumagundane.Le miphumela ingase ibe ngenxa yomphumela wokuvimbela walo muthi emisebenzini ye-NADPH oxidase kanye ne-TGF-β1 kanye nomthelela wayo ovuselelayo ku-GST.
