I-Lipase kusuka ku-porcine pancreas CAS: 9001-62-1 Brown kuya ku-beige powder
| Inombolo Yekhathalogi | XD90387 |
| Igama Lomkhiqizo | I-Lipase kusuka ku-porcine pancreas |
| I-CAS | 9001-62-1 |
| I-Molecular Formula | N/A |
| Isisindo samangqamuzana | N/A |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 35079090 |
Ukucaciswa Komkhiqizo
| Umlotha | <12% |
| AS | <2mg/kg |
| Pb | <2mg/kg |
| Okuqukethwe Amanzi | <8% |
| Isivivinyo | 99% |
| Umsebenzi we-Enzyme | >30000u/g |
| Ukubukeka | Okunsundu kuya ku-beige powder |
| Iqembu le-Coliform | <30MPH/100g |
| Okokusetshenziswa kocwaningo kuphela, hhayi okomuntu | ukusetshenziswa kocwaningo kuphela, hhayi ukusetshenziswa komuntu |
Ukuguqulwa kwe-triglyceride (TG) metabolism kuma-vascular smooth muscle cells (SMC) cishe kungenzeka kuhlotshaniswe ne-phenotype ethile, nakuba lokhu kungakacaciswanga.I-Adipose triglyceride lipase (ATGL) yenza umsebenzi omkhulu we-TG wokuvuselela kuwo womabili amaseli e-adipotic nangewona awe-adipotic.Ocwaningweni lwamanje, sihlukanise i-SMC kumagundane angenayo i-ATGL (ATGL(-/-)mSMC).I-ATGL(-/-)mSMC ibonise ukunqwabelana kwe-TG okuzenzakalelayo okunempendulo ephansi ye-mitogenic kanye nokusho kwemisipha ebushelelezi (SMA) uma kuqhathaniswa ne-ATGL (+/+) mSMC.Amaphesenti amaseli e-_-galactosidase ahlotshaniswa nokuzwela kwe-senescence nawo anyuswa ku-ATGL(-/-)mSMC.I-PCR yesikhathi sangempela elandelwa ukuhlolwa ngokuhlaziywa kwe-DNA okugxilile kwembula inkulumo elawulwa phezulu ye-glucokinase (1.7-fold), i-lipoprotein lipase (3.8-fold) ne-interleukin-6 (3.7-fold) kanye nokubonakaliswa okulawulwa phansi kokukhula kwe-vascular endothelial. i-factor-A (0.2-fold), uhlobo lwe-collagen I (0.5-fold), kanye nesici sokukhula esishintshayo-_ (0.4-fold) ku-ATGL(-/-)mSMC uma kuqhathaniswa ne-ATGL(+/+)mSMC.Okulandelayo, ukudluliswa kofuzo lwe-ectopic lwe-ATGL yomuntu kwazanywa kusetshenziswa i-doxycycline (Dox) -regulatable myc-DDK-tagged adenovirus vector (AdvATGL).Ukutheleleka kwe-AdvATGL kuphumele ekuncipheni kokunqwabelana kwe-TG ngokusabela okuphakeme kwe-mitogenic kanye nenkulumo ye-SMA, futhi kwehle izinombolo zamaseli e-senescent ku-ATGL(-/-)mSMC.Ngaphezu kwalokho, iphethini yesisho sofuzo esichezukile ku-ATGL(-/-)mSMC ingahle ilungiswe.Idatha yethu iphakamisa ukuthi i-ATGL(-/-)mSMC ine-phenotype ehlukile engase ihlobane ne-vascular pathogenesis.Ipulasitiki yama-phenotypes e-SMC ahlotshaniswa ne-lipid metabolism ingaba inhloso yokwelapha.
