N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% Impuphu emhlophe
| Inombolo Yekhathalogi | I-XD90194 |
| Igama Lomkhiqizo | I-ADA (N-(-2-Acetamido)iminodiacetic acid) |
| I-CAS | 26239-55-4 |
| I-Molecular Formula | I-C6H10N2O5 |
| Isisindo samangqamuzana | 190.15 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29241900 |
Ukucaciswa Komkhiqizo
| Fe | <5ppm |
| Pb | <5ppm |
| Ukulahlekelwa Ekumisweni | <0.5% |
| Umlotha one-sulfate | <0.1% |
| Ukubukeka | Impushana emhlophe |
| Ezinye Izincibilikisi | Lutho |
| Isikhathi Sokuhlakazeka (9g ku-91ml 1M NaOH, Ukugqugquzelwa Kwezibuthe) | <1min |
| I-A300 ( 9% ku-1 M NaOH) | <0.08% |
| Inani lamaphoyinti okugcina Aqashelwe kwijika le-titration | Ababili kuphela |
| Ububanzi be-pH obuchaza indawo yokugcina ye-Titration | 9.1 - 10.1 |
| Ukunyibilika (9% ku-1M NaOH) | Icacile futhi Ayinambala |
| Usuku lokukhiqiza | |
| Amanzi KF | <1% |
| I-Assay (Titration) ngesisekelo esomisiwe | >99.0% |
| I-infrared | Iyahambisana |
I-nucleoside adenosine isebenza ezinhlelweni zezinzwa nenhliziyo nge-A2A receptor (A2AR).Ekuphenduleni izinga le-oksijini ezicutshini, ukugxila kwe-adenosine ku-plasma kulawulwa ikakhulukazi ngokuhlanganisa kwayo nge-CD73 nangokucekelwa kwayo yi-adenosine deaminase (ADA).I-cell-surface endopeptidase CD26 ilawula ukugcwala kwama-peptide e-vasoactive kanye ne-antioxidant futhi ngaleyo ndlela ilawula ukutholakala komoya-mpilo ezicutshini kanye nokuphendula kwengcindezi ye-oxidative.Nakuba ukuvezwa ngokweqile kwe-adenosine, i-CD73, i-ADA, i-A2AR, ne-CD26 ekuphenduleni i-hypoxia kubhalwe kahle, imiphumela yezimo ze-hyperoxic kanye ne-hyperbaric kulezi zakhi idinga ukucatshangelwa okwengeziwe.Amagundane kanye nomugqa weseli we-murine Chem-3 oveza i-A2AR avezwe kubha engu-0.21 O2, ibha engu-0.79 N2 (izimo zasemhlabeni; i-normoxia);1 ibha O2 (hyperoxia);2 ibha O2 (hyperbaric hyperoxia);0.21 ibha O2, 1.79 ibha N2 (hyperbaria).I-Adenosine plasma concentration, CD73, ADA, A2AR expression, kanye nomsebenzi we-CD26 kubhekiswe ku-vivo, futhi ukukhiqizwa kwe-cAMP kubhekiswe ku-cellulo.Ngoba ezimeni ze-vivo, i-1) i-hyperoxia yehla izinga le-adenosine plasma kanye ne-T cell surface CD26 umsebenzi, kuyilapho yandisa inkulumo ye-CD73 kanye nezinga le-ADA;I-2) i-hyperbaric hyperoxia ijwayele ukukhulisa umkhuba;kanye ne-3) i-hyperbaria yodwa yayingenalo ithonya elibalulekile kule mingcele.Ebuchosheni nase-cellulo, i-1) i-hyperoxia yehla inkulumo ye-A2AR;I-2) i-hyperbaric hyperoxia ikhulise umkhuba;kanye ne-3) i-hyperbaria iyodwa ibonise umphumela onamandla kakhulu.Sithole iphethini efanayo mayelana nakho kokubili ukuhlanganiswa kwe-A2AR mRNA ebuchosheni nokukhiqizwa kwe-cAMP kumaseli e-Chem-3.Ngakho-ke izinga eliphezulu le-oxygen livame ukwehlisa indlela ye-adenosinergic kanye nomsebenzi we-CD26.I-Hyperbaria iyodwa ithinte kuphela inkulumo ye-A2AR nokukhiqizwa kwe-cAMP.Sixoxa ngokuthi izindlela ezinjalo ezibangelwa i-hyperoxygenation zingakhawulela kanjani, nge-vasoconstriction, ukunikezwa komoya-mpilo ezicutshini kanye nokukhiqizwa kwezinhlobo ze-oxygen esebenzayo.
