I-N- Acetyl -L-cysteine CAS: 616-91-1 98% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | XD90127 |
| Igama Lomkhiqizo | N-Acetyl-L-cysteine |
| I-CAS | 616-91-1 |
| I-Molecular Formula | I-C5H9NO3S |
| Isisindo samangqamuzana | 163.1949 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29309016 |
Ukucaciswa Komkhiqizo
| I-Melting Point | 106-112°C |
| Ukuzungezisa okuqondile | +21°-+25° |
| Izinsimbi ezinzima | <10ppm |
| I-Arsenic | <1ppm |
| pH | 2.0-2.8 |
| Ukulahlekelwa Ekumisweni | ubuningi 1.0% |
| I-sulfate | <0.03% |
| Isivivinyo | 98% iminithi |
| Insimbi | <20ppm |
| Izinsalela ekushiseni | ubuningi .5% |
| I-ammonium | <0.02% |
| cl | <0.04% |
| Ukubukeka | I-crystalline powder emhlophe |
| Isimo Sesixazululo | >98% |
I-N-Acetyl-L-cysteine i-amino acid e-acetylated ene-antioxidant ne-mucolytic properties.Le misebenzi emibili ikhombise ukuthi i-N-Acetyl-L-cysteine ibalulekile ekwelapheni ngamakhemikhali kwe-cystic fibrosis, lapho i-antioxidant/eyehlisayo yenhlanganisela ithuthukisa isimo sokungalingani kwe-systemic redox se-CF kanye nezakhiwo ze-mucolytic ze-compound ezithiya ukuminyana nokuvuvukala okuhlobene nalesi simo se-redox.Njenge-mucolytic, i-N-Acetyl-L-cysteine isebenza ukuhlakaza izibopho ze-disulfide kuwo wonke ama-mucoprotein, ikhulule futhi isuse i-viscosity yesikhwehlela.I-N-Acetyl-L-cysteine ibonisa isenzo sokuncoma ku-glutathione, kokubili okubonisa umsebenzi we-antioxidant ngokusebenzisa ukusebenza kwawo kwe-thiol, futhi kokubili kuboniswa ukuvikela ekucindezelekeni kwe-peroxidative okuhlobene nokushaqeka kwe-septic.I-N-Acetyl-L-cysteine iphinde yaboniswa ukuthi yenza i-apoptosis kumaseli emisipha abushelelezi e-vascular, okubonisa ukuthi lawa maseli asabela ngendlela ehlukile ekushintsheni kwesimo sokunciphisa i-oxidation kunezinye izicubu ezivame ukuvikelwa ukuba khona kwama-antioxidants.Lokhu kuhlobana okumangazayo kumaseli emisipha abushelelezi emithambo kubonisa i-N-Acetyl-L-cysteine njengokungenelela okuthembisayo ekwandeni kwe-arteriosclerotic yalawa maseli.
Izakhiwo zamakhemikhali: I-N-acetyl-L-cysteine white crystalline powder, enephunga elifana nelikagalikhi kanye nokunambitheka okumuncu.IHygroscopic, inyibilika emanzini noma ethanol, ayincibiliki ku-ether ne-chloroform.Ine-acidic kusisombululo esinamanzi (pH2-2.75 ku-10g/LH2O), mp101-107℃Chemicalbook.Lo mkhiqizo ungowosuselwe ku-N-acetylated we-cysteine.I-molecule iqukethe iqembu le-sulfhydryl, elinganqamula isibopho se-disulfide (-SS-) sesibopho se-mucin peptide, ngaleyo ndlela iguqule iketango le-mucin libe iketango elincane le-peptide yamangqamuzana, linciphise Ngenxa ye-viscosity ye-mucin, lo mkhiqizo uyancibilika. umuthi we-viscous sputum, isikhwehlela esikhukhumele kanye namafinyila okuphefumula.
ukusebenzisana kwemithi:
1. Akufanele isetshenziswe kanye ne-penicillin, i-cephalosporin kanye nemithi elwa namagciwane ye-tetracycline, njengoba lena yakamuva ingase ingasebenzi.
2. Inhlanganisela noma okunye ukusetshenziswa ne-isoproterenol kungathuthukisa umphumela wokwelapha futhi kunciphise ukusabela okubi.
3. Gwema ukuthintana nezitsha zensimbi nezerabha, ama-oxidants, nomoya-mpilo.
Okusetshenziswayo: ama-reagents ebhayoloji, izinto zokusetshenziswa, i-thiol (-SH) ku-molecule inganqamula iketango le-disulfide (-SS) elixhuma iketango le-mucin peptide ku-phlegm yamafinyila.I-Mucin iphendula i-Chemicalbook ibe iketango elincane le-peptide yamangqamuzana, elinciphisa i-viscosity yesikhwehlela;ingakwazi futhi ukuphula imicu ye-DNA ku-sputum e-purulent, ngakho ayikwazi nje ukuhlakaza isikhwehlela esimhlophe esimhlophe kodwa futhi nesikhwehlela esi-purulent.
Ukusetshenziswa: Emithi, isetshenziswa njengesidakamizwa esihlakaza i-phlegm.Ocwaningweni lwe-biochemical, isetshenziswa njengekhambi lokuqedwa kwe-phlegm kanye nobuthi be-acetaminophen kwezokwelapha.
Ukusetshenziswa: Ocwaningweni lwe-biochemical, kwezokwelapha, isetshenziswa njengesidakamizwa esincibilikisa i-phlegm kanye nekhambi lobuthi be-acetaminophen.
Ukusetshenziswa: Ama-biochemical reagents, umuthi, lo mkhiqizo usetshenziswa njenge-expectorant, okuthiwa kulula ukuyihlanza i-phlegm futhi kulula ukukhwehlela.Kunomphumela wokubola esikhwehleleni se-viscous.Indlela yokusebenza ukuthi iqembu le-sulfhydryl eliqukethwe esakhiweni samangqamuzana alo mkhiqizo linganqamula isibopho se-disulfide I-Chemicalbook esekeyini ye-polypeptide ye-mucin esikhwehleleni samafinyila, ibolise i-mucin, yehlise i-viscosity yesikhwehlela, futhi isenze sibe uketshezi futhi kube lula ukusikhipha. khwehlela.Ifanele izifo zokuphefumula ezibukhali nezingamahlalakhona ezinezikhwehlela ezinzima futhi okunzima ukuzilindela, kanye nezimpawu ezibucayi zobunzima bokumunca ngenxa yokuvinjwa kwenani elikhulu le-phlegm enamathelayo.
Ukusetshenziswa: I-N-acetyl-L-cysteine ingasetshenziswa njengesidakamizwa esihlakaza i-phlegm.Ilungele ukuvimbela ukuphefumula okubangelwa inani elikhulu lokuvinjelwa kwe-phlegm okunamathelayo.Ngaphezu kwalokho, ingasetshenziswa futhi ukuqeda ubuthi obunobuthi be-acetaminophen.Ngenxa yokuthi lo mkhiqizo unephunga elikhethekile, ukuwuthatha kungabangela kalula isicanucanu nokuhlanza.Inomphumela ovuselelayo emgudwini wokuphefumula futhi ingabangela i-bronchospasm.Isetshenziswa ngokuhambisana nama-bronchodilators afana ne-isoproterenol kanye nethuluzi lokumunca isikhwehlela ukukhipha isikhwehlela.Akufanele ihlangane nezinsimbi (ezifana ne-Fe, Cu), irabha, ama-oxidants, njll. Akufanele isetshenziswe kanye nama-antibiotics afana ne-penicillin, i-cephalosporin, i-tetracycline, njll, ukuze inganciphisi umphumela wayo we-antibacterial.Sebenzisa ngokuqapha ezigulini ezine-asthma ye-bronchial.
