Imikhiqizo

Isidakamizwa esisha sokwehlisa isisindo kanye nesehlisa i-lipid: I-Orlistat iwuhlobo olusha lomuthi wokwehlisa isisindo nowokwehlisa i-lipid owaziwa emhlabeni wonke okwamanje.Ngokudayiswa konyaka kwezigidi ezingu-538 zamaRandi, i-orlistat okwamanje ithatha i-80% yemakethe yokulahlekelwa isisindo emhlabeni wonke, futhi ukuthengiswa konyaka eHong Kong, i-China iyodwa ifinyelela ku-US $ 80 million.Njengamanje ukuphela kwesidakamizwa se-OTC sokunciphisa isisindo emhlabeni.Bangaphezu kuka-40,000,000 abantu emhlabeni jikelele abayithathile futhi banciphisa isisindo ngempumelelo.Njengamanje iwumkhiqizo wokulahlekelwa isisindo othengiswa kakhulu.Isebenza ngempumelelo ekulahlekeni kwesisindo.I-Orlistat iyi-lipase inhibitor enamandla futhi esebenza isikhathi eside.Ngokuvimbela ngokuqondile ukumuncwa komzimba kwamafutha ekudleni, uma ukudla kwama-calories namafutha kungaphansi kokusetshenziswa, amafutha omzimba ayancipha ngokwemvelo, ukuze kuzuzwe injongo yokulahlekelwa isisindo.Kuphephile ukulahlekelwa isisindo, izithako ezisebenzayo azifaki ukuhamba kwegazi, futhi ungenzi ohlelweni lwezinzwa oluphakathi.

I-Orlistat iyi-lipase inhibitor esebenza isikhathi eside futhi enamandla, impushana emhlophe noma emhlophe emazingeni okushisa asekamelweni, ayincibiliki emanzini, i-chloroform, futhi incibilika kalula ku-ethanol.Izingosi ze-serine ezisebenzayo ze-gastric lipase kanye ne-pancreatic lipase zakha izibopho eziqinile zokuvala ama-enzyme.Amafutha asekudleni awakwazi ukubola abe ama-fatty acids mahhala kanye ne-monoacylglycerols, ngakho-ke amafutha awakwazi ukumuncwa futhi asetshenziswe, ngaleyo ndlela kunciphe ukudla okunama-calories omzimba nokulawula isisindo somzimba.Lo muthi awudingi ukumuncwa kwesistimu ukuze usebenze.Ngemithamo evamile, ukumuncwa kwamafutha kungavinjelwa ngo-30%.Ayivami ukumuncwa ngemva kokuphathwa ngomlomo, futhi ingenziwa ingasebenzi yi-metabolism emgudwini wamathumbu.Isizinda se-metabolic esodongeni lwepheshana lesisu, futhi uhhafu wempilo wokuqeda cishe amahora ayi-14 kuya kwayi-19.Cishe i-97% yalo mkhiqizo ikhishwa ngendle, okuthi i-83% yayo ikhishwe ngendlela yayo yasekuqaleni.

Ingasetshenziswa emtholampilo ekukhuluphaleni kanye ne-hyperlipidemia.Ngaphansi kwezimo ezijwayelekile, umthamo we-120 mg ungathathwa ngomlomo, kathathu ngosuku, ngokudla noma ihora elingu-1 ngemuva kokudla.Isisindo singaqala ukwehla ngemva kwamaviki ama-2 wokuphuza umuthi.Ingathathwa ngokuqhubekayo izinyanga eziyisi-6 kuye kweziyi-12.Uma umthamo unyuswa waba ngaphezu kuka-400 mg ngosuku, umphumela wawo ngeke usathuthukiswa.