Iplatinamu ku-carbon Cas ecushiwe:7440-06-4
| Inombolo Yekhathalogi | XD90696 |
| Igama Lomkhiqizo | IPlatinum kukhabhoni ecushiwe |
| I-CAS | 7440-06-4 |
| I-Molecular Formula | Pt |
| Isisindo samangqamuzana | 195.08 |
| Imininingwane Yesitoreji | 2-8°C |
| Ikhodi Yentela Evumelanisiwe | 28439000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | i-silvery-grey meta |
| Isivivinyo | 99% |
| Dumfutho | 21.45 |
| Iphoyinti lokuncibilika | 1772℃ |
| Iphuzu elibilayo | 3827℃ |
| I-Refractive Index | n20/D 1.347 |
| Iphoyinti le-Flash | 3825°C |
| Umfutho we-vapor | 0 mm Hg (cishe) (NIOSH, 2016) |
Ukuhlola ama-anticancer asekelwe ku-platinum ahlukile ekwakhekeni nasekusebenzeni kwemodi ye-cisplatin yendabuko ngokwenza i-adduct ye-intrastrand 1,2 GpG esebenza kabili, i-monofunctional platinum+DNA nokusebenzisana okungapheli kwase kuhlolisisiwe.Kwabikwa ukuthi ama-ejenti asekelwe ku-testosterone-based platinum(II) asebenzayo aveza umsebenzi ophezulu wokulwa nomdlavuza.Ngaphezu kwalokho, kuphinde kwatholakala ukuthi i-testosterone-based platinamu ejenti ingabangela i-DNA helix ukuthi ikhululeke futhi igobe phezu kwe-non-testosterone-based platinum agents.Kodwa-ke, izindlela zokusebenzisana zalawa ma-ejenti e-platinum ane-DNA ezingeni le-athomu awakacaci kuze kube manje.Emsebenzini wamanje, sisebenzise ukulingiswa kwe-molecular dynamics (MD) kanye nezibalo ze-DNA conformational dynamics ukuze sifunde izakhiwo zokuhlanekezelwa kwe-DNA ye-testosterone- based platinum+DNA, the improved testosterone-based platinum+DNA kanye ne-non-testosterone-based platinum+DNA adducts.Imiphumela ibonisa ukuthi ukusebenzisana kwe-agent ethuthukisiwe esekelwe ku-testosterone-based platinamu ene-molecule ye-DNA kungabangela ukuhlanekezela okukhulu kwe-DNA kunokusebenzelana kobuso be-groove ye-ejenti eqinile esekelwe ku-testosterone ene-molecule ye-DNA.Uphenyo olwengeziwe lwe-ejenti ye-platinamu engeyona i-testosterone-based luveza ukwenzeka koshintsho olungasho lutho lokuhlangana kwe-DNA ngenxa yokungabikho kwe-testosterone ligand kumenzeli onjalo.Ngokusekelwe ekuhlaziyweni kokuguquguquka kwe-DNA, ukunyakaza kwesisekelo se-DNA okuhlobene nezinguquko zepharamitha ye-DNA groove kanye nokubhujiswa kwebhondi ye-hydrogen yamapheya esisekelo se-DNA nakho kwaxoxwa ngakho kulo msebenzi. i-testosterone-based platinum+DNA adduct ethuthukisiwe, ehlukile ekusebenzisaneni kobuso be-groove okubangelwa isixhumanisi esiqinile ku-ejenti yeplatinamu esekwe ku-testosterone.Uphenyo lwamanje luhlinzeka ngolwazi oluwusizo lokuguqulwa kwe-DNA okuthintekayo yi-testosterone-based platinamu complex ezingeni le-athomu.
