I-Polystyrene sulfonic acid CAS: 28210-41-5
| Inombolo Yekhathalogi | XD90753 |
| Igama Lomkhiqizo | I-Polystyrene sulfonic acid |
| I-CAS | 28210-41-5 |
| I-Molecular Formula | I-C8H8O3S |
| Isisindo samangqamuzana | 184.212 |
| Imininingwane Yesitoreji | I-ambient |
Ukucaciswa Komkhiqizo
| Ukubukeka | Uketshezi oluhlanzekile |
| Isivivinyo | 99% |
I-Hyperkalemia ngesikhathi se-renin-angiotensin-aldosterone system inhibition (RAAS-I) ingase ivimbele ukudosa okuphezulu.Izinketho zokwelapha zihlanganisa i-sodium polystyrene sulfonate potassium binding resins, kodwa kukhona ukukhathazeka kokuphepha nokusebenza ngempumelelo, okuhlanganisa ne-colonic necrosis (CN) ehlobene.Amanye ama-ejenti acutshunguliwe, kodwa usizo lwezindleko alulinganiselwanga. Senze ukuhlaziya okuwusizo kweziguli ezingalaliswa ≥ ezineminyaka engu-18 ubudala ezithola i-RAAS-I engapheli, enomlando we-hyperkalemia noma isifo sezinso esingamahlalakhona, esinqunyelwe i-sodium polystyrene sulfonate. noma i-resin ebophayo "yesidakamizwa X" ye-hyperkalemia engapheli.Idatha yatholwa ezincwadini ezikhona.Sisebenzise imodeli yokuhlaziya isinqumo nge-Monte Carlo probabilistic sensitivity analysis, ngokombono womkhokhi wezempilo kanye nomkhathizwe wezinyanga eziyi-12.Izindleko zikalwe ngamadola aseMelika.Ukuphumelela kukalwe ngeminyaka yokuphila elungiswe ngekhwalithi (ama-QALY), kanye nezilinganiso ezikhuphukayo zokuphumelela kwezindleko (ama-ICER). Umuthi X wawungeke ubize ngaphezu kuka-$10.77 ngomthamo wansuku zonke ukuze ungabizi, ngokuzimisela ukukhokha ( WTP) umkhawulo wama-$50,000/QALY.Ngo-$40.00 ngomthamo wansuku zonke, umuthi u-X uzuze isilinganiso esikhuphukayo sokusebenza kahle kwezindleko zama-$26,088,369.00 nge-QALY ngayinye ezuziwe.Ukuhlaziywa kokuzwela kwendlela eyodwa kubonise i-sodium polystyrene sulfonate ukuba inketho engabizi kakhulu yezehlakalo ze-CN ≤ 19.9%.Imikhawulo ihlanganisa ulwazi olungaphelele ngemiphumela yeziguli ezilaliswa ngaphandle kanye nokuntuleka kwedatha eqhathanisa ngokuqondile i-sodium polystyrene sulfonate kwezinye izinto ezingase zibe khona.Izindlela ezihlukile zingase zingabizi ngaphandle uma zinenani elifanayo ne-sodium polystyrene sulfonate.Lokhu kuhlaziya kungase kuqondise izinqumo eziphathelene nokwamukelwa kwamanye ama-ejenti okulawula i-hyperkalemia engapheli, futhi kuphakamise ukuthi i-sodium polystyrene sulfonate isetshenziswe njengokulawula okusebenzayo ekuhlolweni komtholampilo kwalawa ma-ejenti.
