I-Riboflavin Cas: 83-88-5 I-Orange powder 99%
| Inombolo Yekhathalogi | XD90448 |
| Igama Lomkhiqizo | I-Riboflavin |
| I-CAS | 83-88-5 |
| I-Molecular Formula | I-C17H20N4O6 |
| Isisindo samangqamuzana | 376.36 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29362300 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ewolintshi |
| Isivivinyo | >99% |
| Izinsimbi ezinzima | <0.001% |
| AS | <0.002% |
| Ukulahlekelwa Ekumisweni | <0.5% |
| Izinsalela ekushiseni | <0.2% |
| Ukujikeleza okuqondile okubonakalayo | -120 kuya ku-140 |
I-Riboflavin, eyaziwa nangokuthi uvithamini B2, ithuthwa ngolwelwesi lwebhayoloji iye ezithweni ezahlukahlukene ngezinhlelo zokuthutha.I-riboflavin transporter RFVT3 ivezwa emathunjini amancane futhi kuye kwaphakanyiswa ukuthi ifakwe kulwelwesi lwama-apical lwamaseli e-epithelial yamathumbu.Kulolu cwaningo, siphenye ukusebenza kwe-RFVT3 ekumunceni i-riboflavin kusetshenziswa amaseli we-epithelial T84 wamathumbu kanye negundane lamathumbu amancane.Amaseli e-T84 aveze i-RFVT3 futhi alondoloziwe unidirectional riboflavin ezokuthutha okuhambisana nokumuncwa emathunjini.Ukuthathwa kwe-apical [(3)H] kwe-riboflavin bekuncike ku-pH kumaseli e-T84.Lokhu kuthatha akuthintwanga ukuncipha kwe-Na(+) ku-apical pH 6.0, nakuba kwehle kakhulu nge-apical pH 7.4.Ukuthathwa kwe- [(3)H] i-riboflavin kusukela kuhlangothi lwe-apical lwamaseli e-T84 kuvinjwe ngokuvelele i-RFVT3 inhibitor ekhethiwe i-methylene eluhlaza okwesibhakabhaka futhi kwehle kakhulu ngokudluliselwa kwe-RFVT3-i-RNA ephazamisa kancane.Emgudwini wamathumbu, i-RFVT3 yavezwa ku-jejunum ne-ileum.Ukuqina kwegundane kwe-jejunal kanye ne-ileal ye-[(3)H] riboflavin kukalwa ngendlela ye-in situ cloop-loop futhi kwehliswa kakhulu nge-methylene eluhlaza okwesibhakabhaka.Le miphumela iphakamisa ngokuqinile ukuthi i-RFVT3 izobandakanyeka ngokusebenzayo ekumunceni i-riboflavin kulwelwesi lwama-apical lwamaseli we-epithelial wamathumbu.
