I-Streptavidin evela ku-Streptomyces avidinii CAS:9013-20-1
| Inombolo Yekhathalogi | XD90329 |
| Igama Lomkhiqizo | I-Streptavidin evela ku-Streptomyces avidinii |
| I-CAS | 9013-20-1 |
| I-Molecular Formula | I-C14H17BrClNO2S |
| Isisindo samangqamuzana | 378.71 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 35040090 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| Isivivinyo | 99% |
| Okokusetshenziswa kocwaningo kuphela, hhayi okomuntu | ukusetshenziswa kocwaningo kuphela, hhayi ukusetshenziswa komuntu |
I-Alkyne-hinged 3-fluorosialyl fluoride (DFSA) equkethe iqembu le-alkyne iboniswe njenge-mechachanic-based target-specific irreversible inhibitor ye-sialidase.I-ester-protected analog DFSA (PDFSA) iyi-membrane-permeable precursor ye-DFSA eklanyelwe ukusetshenziswa kumaseli aphilayo, futhi yaboniswa ukwenza ama-covalent adducts anegciwane, amagciwane, nama-sialidase abantu.I-adduct ye-fluorosialyl-enzyme ingahlanganiswa ne-azide-annexed biotin ngokusabela ngokuchofoza futhi itholwe amasiginali wokubika aqondene ne-streptavidin.I-Liquid chromatography-mass spectrometry/mass spectrometry analysis ezingcezuni ze-tryptic peptide ibonisa ukuthi i-3-fluorosialyl moiety ilungisa izinsalela ze-tyrosine ze-sialidase.I-DFSA yasetshenziselwa ukukhombisa ukutheleleka komkhuhlane kanye nokuhlonzwa kokuba sengozini kwegciwane emuthini wokulwa nomkhuhlane i-oseltamivir acid, kuyilapho i-PDFSA yasetshenziselwa ukuthwebula kwe-in situ kwezinguquko zomsebenzi we-sialidase kumaseli aphilayo.
