I-Tazobactam Cas: 89786-04-9
| Inombolo Yekhathalogi | XD92373 |
| Igama Lomkhiqizo | I-Tazobactam |
| I-CAS | 89786-04-9 |
| Ifomu le-Molecularla | I-C10H12N4O5S |
| Isisindo samangqamuzana | 300.29 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe ukuya kokumhlophe |
| U-Asay | 99% iminithi |
| Amanzi | <0.5% |
| Ukuzungezisa okuqondile | +127 ukuze +139 |
| Izinsimbi ezinzima | <20ppm |
| Izinsalela ekushiseni | <0.1% |
| Ukungcola Okuphelele | <1.0% |
I-Tazobactam iyi-penicillanic acid sulfone efundisa okufanayo ne-sulbactam.Inamandla kakhulu e-β-lactamaseihibitor kune-sulbactam futhi inomsebenzi obanzi kancane kune-clavulanic acid.Ine-antibacterialactivity ebuthakathaka kakhulu.I-Tazobactam itholakala ngomthamo ongashintshi, izinhlanganisela ezijovayo ne-piperacillin, i-penicillin ebanzi ehlanganisa isilinganiso esingu-8:1 se-piperacillin sodium kuya ku-tazobactamsodium ngesisindo futhi imakethwa ngaphansi kwegama lokuhweba elithi Zosyn. I-pharmacokinetics yemithi emibili ifana kakhulu.Bobabili banesigamu sokuphila okufushane (t1/2 ～1 ihora), bane-protein encane, bane-metabolism encane kakhulu, futhi bakhishwa amafomu angasebenzi emchameni ngokugxila okuphezulu.
Izinkomba ezigunyaziwe ze-piperacillin–tazobactamcombination zihlanganisa ukwelashwa kwe-appendicitis, i-postpartumendometritis, nesifo sokuvuvukala kwe-pelvic esibangelwa i-β-lactamase-ekhiqiza i-E. coli ne-Bacteroides spp., izifo zesakhiwo sesikhumba nesikhumba ezibangelwa i-β-lactamase-producingS.aureus, kanye nenyumoniya ebangelwa ama-β-lactamase-producingstrains of H. influenzae.
