Imikhiqizo

I-Telithromycin yethulwa okokuqala eJalimane njengendlela yokwelapha ngomlomo kanye ngosuku ngezifo zokuphefumula okuhlanganisa inyumoniya etholwa umphakathi, ukwanda kwamagciwane okubangelwa ukucinana kwemigudu yokuphefumula engapheli, i-acute sinusitis kanye ne-tonsillitis/pharyngitis.Lokhu okuphuma ku-semisynthetic kwe-natural macrolide erythromycin i-ketolide yokuqala emakethe, ikilasi elisha lama-antibiotics ane-C3-ketone esikhundleni seqembu le-L-cladinose.I-ejenti ye-antibacterial enamalungu angu-14 indandatho ivimbela ukuhlanganiswa kwamaprotheni ebhaktheriya ngokubopha izizinda ezimbili ze-50S subunit yama-ribosomes ebhaktheriya.Ibonisa umsebenzi onamandla we-in vitro ngokumelene namagciwane avamile okuphefumula ahlanganisa i-Streptococcus pneumoniae, i-Haemophilus influenzae, i-Moraxella catarrhalis kanye ne-Streptococcus pyogenes kanye namanye amagciwane angenayo i-atypical.Iqembu le-3-keto linikeza ukusimama kwe-acidic okukhulayo kanye nokunciphisa ukufakwa kwe-macrolide-lincosamide-streptogramin B ukumelana okuvame ukubonwa ngama-macrolides.Izinsalela ze-carbamate ezifakwe esikhundleni se-C11-C12 azibonakali nje ukwandisa ukuhlobana kwendawo ebopha i-ribosomal kodwa futhi ukuzinzisa inhlanganisela ngokumelene ne-esterase hydrolysis futhi igweme ukumelana ngenxa yokuqedwa kwama-macrolides kuseli ngepompo ye-efflux efakwe isakhi sofuzo se-mef kumagciwane athile. .I-Telithromycin iyi-inhibitor yokuncintisana kanye ne-substrate ye-CYP3A4.Nokho, ngokungafani nama-macrolide amaningana njenge-troleandomycin, ayakhi inhibitory ezinzile ye-CYP P-450 Fe2+-nitrosoalkane metabolite complex okungenzeka ibe ne-hepatotoxic.Isidakamizwa sibekezelelwa kahle futhi sisatshalaliswa kahle ezicutshini zamaphaphu, uketshezi lwe-bronchial, amathani namathe.Kuvela ukuthi kugxilwe kakhulu kuma-azurophil granules we-polymorphonuclear neutrophils ngaleyo ndlela kube lula ukulethwa kwawo kumagciwane e-phagocytosed.