Imikhiqizo

I-compound tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2--[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2, I-2-dimethyl-1,3-dioxane-4-acetate iyinhlanganisela eyinkimbinkimbi yezinto eziphilayo engase isetshenziswe emikhakheni ehlukahlukene kuhlanganise nemithi, amakhemikhali e-agrochemicals, kanye ne-chemistry yezinto. i-pyrimidine, nendandatho ye-dioxane.Ukuba khona kwamaqembu e-tert-butyl kanye ne-acetate kuphakamisa ukuzinza okungaba khona kanye nokulula ukuphatha.Endimeni yezemithi, le nhlanganisela ingase ibe namandla njengesithako esisebenzayo semithi (i-API) sokuthuthukiswa kwemithi emisha.Ukuba khona kweqembu le-pyrimidine kuphakamisa ukusebenzisana okungenzeka okuhloswe kwezinto eziphilayo, okwenza kube ikhandidethi elibalulekile lokuthola izidakamizwa.Iqembu le-4-fluorophenyl elixhunywe ku-pyrimidine liyaziwa ngokubaluleka kwalo ekwakhiweni kwezidakamizwa ngenxa yomnikelo walo ekubopheni ukuhlangana kanye nokusebenza kwe-bioactivity.Ingase ithuthukise kakhulu umsebenzi wesayensi yezinto eziphilayo noma ukukhetha okuqondisiwe.Iqembu le-ethonyl elikhona kwinhlanganisela lethula ukwahlukahlukana okwengeziwe kwesakhiwo, okungaba nenzuzo ekuguquleni amandla enhlanganisela, ukusebenza kahle, kanye nezakhiwo zekhemisi.Izinto ezibambele eqenjini le-ethonyl, njengamaqembu e-methyl ne-methylsulfonyl amino, zithuthukisa futhi ukuhlukahluka kwamakhemikhali enhlanganisela futhi zingase zibe nomthelela ekusebenzeni kwayo kwe-bioactivity noma izici ezifana nezidakamizwa. Ngaphezu kwalokho, i-1,3-dioxane ring moiety iye yafakwa ezinhlelweni ezihlukahlukene. , okuhlanganisa njengesithuthukisi sokuncibilika noma njengesistimu yokulethwa kwezinye izinhlanganisela ezisebenzayo.Ukuba khona kwayo kule nhlanganisela kusikisela ukuthi ingase ithuthukise ukunyibilika noma ukuzinza kwenhlanganisela.Ngaphandle kokusetshenziswa kwemithi, le nhlanganisela ingase futhi ithole ukusetshenziswa kumakhemikhali ezolimo njenge-ejenti yokuvikela izitshalo.Ingase ibonise umsebenzi wokubulala izinambuzane ngokumelene nezinambuzane noma ibe neminye imiphumela enenzuzo ekukhuleni kwezitshalo nempilo.Ngaphezu kwalokho, izici zesakhiwo senhlanganisela, njengeqembu le-tert-butyl kanye neringi ye-dioxane, ziyenza ikhange ekusebenziseni kwamakhemikhali wezinto ezibonakalayo.Ingase isebenze njengebhlokhi yokwakha noma isandulela sokuhlanganiswa kwezinto ezisetshenziswayo zenoveli ezinezakhiwo ezihlukile, njengezinto ze-polymeric noma amakhemikhali akhethekile. -6-(1-methylethyl) -2- [methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate iyinhlanganisela enezicelo ezingase zibe khona kwezemithi, i-agrochemicals, kanye namakhemikhali wezinto zokwakha.Isakhiwo sayo samakhemikhali esiyingqayizivele namaqembu asebenzayo aphakamisa ukufaneleka kokuthuthukiswa kwezidakamizwa, ukuvikelwa kwezitshalo, noma ukuhlanganiswa kwezinto ezintsha.Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuhlola ngokugcwele ukusebenza kwayo kwe-bioactivity, ukukhetha okuqondiwe, izakhiwo zekhemisi, nokuphepha ngaphambi kokuthi isetshenziswe ezinhlelweni ezithile.