I-Thiamphenicol Cas: 15318-45-3
| Inombolo Yekhathalogi | XD92378 |
| Igama Lomkhiqizo | I-Thiamphenicol |
| I-CAS | 15318-45-3 |
| Ifomu le-Molecularla | I-C12H15Cl2NO5S |
| Isisindo samangqamuzana | 356.22 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29414000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| U-Asay | 99% iminithi |
| I-Melting Point | 163°C - 167°C |
| Izinsimbi ezinzima | ≤10ppm |
| Ukulahlekelwa Ekumisweni | ≤1.0% |
| Ukujikeleza okuqondile okubonakalayo | -21° -24° |
| I-Chloride | ≤0.02% |
I-Thiamphenicol iyimithi elwa namagciwane ene-spectrum ebanzi i-chloramphenicol, esebenza kangcono kubhaktheriya e-gram-negative kunamagciwane e-gram-positive.Ezingeni lokushisa lasekamelweni, iyimpushana yekristalu emhlophe ukuya kokumhlophe noma ikristalu, engamuncwa ngokushesha futhi ngokuphelele ngokuphathwa ngomlomo, futhi ikhishwa ikakhulukazi ku-prototype isuka emchameni ukuze kusetshenziswe umzimba.Isetshenziswa emtholampilo ekwelapheni ukuphefumula, umgudu womchamo, isibindi nenyongo, i-typhoid nokunye ukuhlinzwa kwamathumbu, izifo zabesifazane kanye nezifo ze-ENT.Ikakhulukazi ekuthelelekeni okuncane kusebenza kakhulu.Inesakhiwo samakhemikhali esifanayo ne-chloramphenicol.I-methyl sulfone yayo yathatha indawo ye-nitro ye-chloramphenicol, eyanciphisa ubuthi bayo, futhi ku-vivo umsebenzi wayo wokulwa namagciwane unamandla izikhathi ezingu-2.5-5 kune-chloramphenicol.Kumagciwane egram-positive, njenge-streptococcus pneumoniae kanye ne-hemolytic streptococcus, inomphumela onamandla kakhulu wokulwa namagciwane, kuyilapho kumagciwane angenayo igram, njenge-Neisseria gonorrhoeae, i-meningococcus, i-lung Bacteroides, i-E. coli, i-Vibrio cholerae, i-Shigella ne-influenza, i-influenza futhi inomphumela oqinile we-antibacterial.Kubhaktheriya anaerobic, i-Rickettsia ne-amoeba, inomphumela wokulwa namagciwane ngezinga elithile.Ine-antimicrobial mechanism efanayo ne-chloramphenicol, evimbela ngokuyinhloko ukuhlanganiswa kwamaprotheni ebhaktheriya.Lesi sidakamizwa simuncwa ngokushesha ngokuphathwa ngomlomo, okufinyelela ekugxilweni okukhulu kwegazi phakathi kwamahora amabili.Ingxenye yempilo yayo ingamahora angu-5, okusho ukuthi yinde kune-chloramphenicol.Amagciwane anokumelana okuphelele nawo kanye ne-chloramphenicol, kanti amagciwane ane-cross-resistance ethile kuwo kanye ne-tetracycline.
I-Thiamphenicol nayo inemiphumela eqinile yokuzivikela komzimba, okuyi-immunosuppressant enhle kakhulu.Indlela yokusebenza kwayo ihluke kakhulu kwamanye ama-immunosuppressive agents.Umphumela we-immunosuppressive uphakeme izikhathi eziningana kune-chloramphenicol.Kungaba njenge-extender esebenzayo yokusabela kokufakelwa kanye nokufakelwa kwe-allogeneic ngokuhlinzwa.
