I-Doxorubicin hydrochloride CAS:25316-40-9 99% I-Orange-red Crystalline powder
| Inombolo Yekhathalogi | XD90367 |
| Igama Lomkhiqizo | I-Doxorubicin hydrochloride |
| I-CAS | 25316-40-9 |
| I-Molecular Formula | C27H29NO11·HCl |
| Isisindo samangqamuzana | 579.98 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| AmanziOkuqukethwe | ≤ 4.0% |
| pH | 4.0-5.5 |
| Ukuncibilika | Incibilika: emanzini, i-methanol ne-isotonic NaCl(aq).Ukungancibiliki kahle ku-chloroform nezinye izinyibilikisi eziphilayo. |
| Izinto Ezihlobene | I-Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Isivivinyo | 99% |
| Izincibilikisi Ezisele | I-acetone notshwala: ≤2.5% / i-acetone: ≤0.5% / i-Methanol: ≤500ppm |
| Noma Ikuphi Okunye Ukungcola | ≤ 0.5% |
| Ukungcola Okuphelele | ≤ 2.0% |
| I-Crystallinity | Ihambisana ne-USP |
| Ukubukeka | I-Crystalline powder ebomvu ebomvu |
| Ukuhlonza | I-HPLC |
Iziguli ezinomdlavuza webele we-P-glycoprotein kanye ne-HER2/neu (HER2) we-receptor-overexpressing ngokuvamile ziba nemiphumela emibi yomtholampilo.Kodwa-ke, abekho imigqa yamaseli omdlavuza webele etholakalayo edayiswayo ayi-HER2/P-glycoprotein ene-double-positive, ekhawulela ucwaningo kulo mkhakha.Sibika ngokuthuthukiswa kanye nokuhlukaniswa komugqa omncane ongazweli emuthini ovela ebeleni eline-HER2-positive. umugqa weseli lomdlavuza ngokudluliswa okuzinzile kwe-ATP-binding cassette (ABC) ilungu lomndeni ongaphansi we-B ilungu elingu-1 (ABCB1) elifaka ikhodi ye-P-glycoprotein.Amazinga e-ABCB1 okubonisa isakhi sofuzo ayephezulu ngemva kokudluliselwa, okuholele ekwandeni kwe-P-glycoprotein izikhathi ezingu-40 isisho.Kuyathakazelisa ukuthi ukudluliswa kwe-ABCB1 kuphinde kwaholela ekwenyukeni okuncane kofuzo lwe-HER2 namazinga wokuvezwa kwamaprotheni.Ukudluliselwa kwe-ABCB1 kwandise amazinga okuvezwa kwe-P-glycoprotein ngokuphawulekayo.Indlela esetshenziswe lapha ukuze kuthuthukiswe lo mzila weseli ifanele ukungeniswa okusheshayo, okuzinzile kwe-P-glycoprotein-mediated drug resistance uma kuqhathaniswa nezindlela ze-tr aditional.Ukuhlolwa kwe-in vitro cytotoxicity kuphakamisa ukuthi lo mugqa weseli unokumelana nezinhlobonhlobo zemithi yokwelapha i-chemotherapeutic.
