I-Doxycycline hyclate CAS: 24390-14-5 99% I-crystalline powder ephuzi
| Inombolo Yekhathalogi | XD90368 |
| Igama Lomkhiqizo | I-Doxycycline hyclate |
| I-CAS | 24390-14-5 |
| I-Molecular Formula | C22H24N2O8·HCl·0.5C2H6O·0.5H2O |
| Isisindo samangqamuzana | 512.94 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29413000 |
Ukucaciswa Komkhiqizo
| Ukungcola A | <2% |
| UkungcolaB | <2% |
| Ukuzungezisa okuqondile | -105 kuya ku-120 |
| pH | 2-3 |
| Ukungcola C | <0.5% |
| UkungcolaD | <0.5% |
| Ukulahlekelwa Ekumisweni | 1.4-2.8% |
| Isivivinyo | 99% |
| Izinsalela ekushiseni | <0.4% |
| Ukumuncwa | 300-335 |
| Noma yikuphi okunye ukungcola okukodwa | <0.5% |
| Ukubukeka | I-crystalline powder ephuzi |
| Ukungcola F | <0.5% |
| UkungcolaE | <0.5% |
| I-Ethyl Alcohol | 4.5 - 6% |
| Ukumuncwa ukungcola | <0.07% |
Ukwakhiwa kwe-Biofilm ekukhishweni kwamazinyo kungase kuholele ku-peri-implant mucositis kanye ne-peri-implantitis elandelayo.Lezi zimo zelashwa ngama-antibiotic afana ne-doxycycline (Doxy).Lapha sisebenzise indlela ye-electrochemical ye-cathodic polarization ukuze simboze i-Doxy endaweni engaphandle yento yokukhipha amazinyo.Indawo ehlanganiswe ne-Doxy ibonise ukuqhuma kukasawoti ogcwele i-phosphate phakathi namahora angu-24 okuqala.Kodwa-ke, inani elibalulekile le-Doxy lahlala phezulu okungenani amaviki ama-2 ikakhulukazi kusampula yamahora angu-5 mA-3 enenani eliphakeme le-Doxy, okusikisela kokubili amandla okuqala kanye nesikhathi eside se-bacteriostatic yendawo eboshiwe.Ikhemistri engaphezulu yahlaziywa nge-x-ray photoelectron spectroscopy kanye ne-ion mass spectrometry yesibili.Isimo sezulu esingaphezulu sihlolwe nge-electron microscopy ye-electronic emission scanner kanye ne-blue-light profilometry.Isikhathi eside se-polarization ukusuka ku-1 h kuye ku-5 h kanye nokuminyana okuphezulu kwamanje ukusuka ku-1 kuye ku-15 mA cm(-2) kubangele inani eliphakeme le-Doxy endaweni engaphezulu.Ubuso bembozwe ungqimba lwe-Doxy ngaphansi kuka-100 nm ngaphandle kwezinguquko eziphawulekayo ku-topography engaphezulu.Impahla ye-antibacterial ye-Doxy-coated surface yahlaziywa nge-biofilm kanye nokuhlolwa kokukhula kwe-planktonic kusetshenziswa i-Staphylococcus epidermidis.Amasampuli ahlanganiswe ne-Doxy anciphisa kokubili ukunqwabelana kwe-biofilm kanye nokukhula kwe-planktonic esikweni lomhluzi, futhi avimbela ukukhula kwamagciwane kumapuleti e-agar.Umthelela we-antibacterial ubunamandla kumasampuli angu-5 mA-3 h ahlanganiswe nenani eliphakeme le-Doxy uma kuqhathaniswa nalelo lika-1 mA-1 h.Ngakho-ke, i-abutment surface ehlanganiswe ne-Doxy inamandla okuvimbela ukoloni lwebhaktheriya lapho ivezwe emgodini womlomo.I-Doxy-coating ingaba yindlela esebenzayo yokulawula i-peri-implant mucositis futhi ivimbele ukuqhubeka kwayo ibe yi-peri-implantitis.
