Imikhiqizo

I-Cystic fibrosis yisifo sofuzo lapho amafinyila angavamile emaphashini ehlotshaniswa nokuba sengozini yokuthola izifo eziqhubekayo.Ukwanda kwamaphaphu yilapho izimpawu zokutheleleka ziba nzima kakhulu.Imithi elwa namagciwane iyingxenye ebalulekile yokwelapha ukushuba futhi ama-antibiotic ahogelwe angasetshenziswa yedwa noma ngokuhambisana nama-antibiotic omlomo ukuze kukhuliswe kakhudlwana noma ngama-antibiotic afakwa emthanjeni ezifweni ezinzima kakhulu.Ama-antibiotics ahogelwe awabangeli imiphumela emibi efana nemithi elwa namagciwane efakwa emthanjeni futhi angase afakazele enye indlela kubantu abangakwazi ukufinyelela kahle emithanjeni yabo.Ukunquma ukuthi ukwelashwa kokuvuvukala kwamaphaphu ngama-antibiotic ahogelwe kubantu abane-cystic fibrosis kuyathuthukisa izinga labo lokuphila, kunciphisa isikhathi sokuphumula. esikoleni noma emsebenzini futhi sithuthukisa ukuphila kwabo kwesikhathi eside.Siseshe i-ClinicalTrials.gov kanye ne-Australia kanye ne-New Zealand Clinical Trials Registry ukuze uthole izinhlolo ezifanele.Usuku lokuseshwa kokugcina: 15 Mashi 2012Siphinde sasesha Irejista Yezivivinyo Ze-Cystic Fibrosis ye-Cochrane Cystic Fibrosis G.Usuku lokuseshwa kokugcina: 01 June 2012.Izilingo ezilawulwa ngokungahleliwe kubantu abane-cystic fibrosis abane-pulmonary exacerbation lapho ukwelashwa ngama-antibiotic ahogelwe kwaqhathaniswa ne-placebo, ukwelashwa okujwayelekile noma enye i-antibiotic ehogeliwe phakathi kwesonto elilodwa namane.Ababhali ababili bokubuyekeza ngokuzimele ukuhlola okufanelekile okukhethiwe, kuhlolwe ubungozi bokuchema esivivinyweni ngasinye kanye nedatha ekhishiwe.Ababhali bezivivinyo ezifakiwe bathintwa ukuze bathole ulwazi olwengeziwe.Izilingo eziyisithupha nabahlanganyeli abangu-208 zifakiwe ekubuyekezweni.Izilingo zazihlukene ekwakhiweni nasekungeneleleni (nokho-ke, zonke zazihlanganisa izivivinyo eziqhathaniswa nemithi yokuhogela ehambisana nemithi elwa namagciwane).Ingozi yokuchema bekunzima ukuyihlola ezivivinyweni eziningi.Imiphumela ayizange ibikwe ngokugcwele futhi idatha elinganiselwe kuphela etholakalayo ukuze ihlaziywe.Izivivinyo ezine zibike eminye imiphumela ngevolumu yokuphelelwa umoya okuphoqelekile ngomzuzwana owodwa futhi azitholanga mehluko omkhulu phakathi kwemithi elwa namagciwane ehogeliwe kanye nokungenelela kwendodana yokuqhathanisa.Kokubili kwalokhu kuhlola kusetshenziswa u-300 mg we-tobramycin ehogeliwe, uguquko lwevolumu yokuphefumula ephoqelelwe ngomzuzwana owodwa lwalufana ne-tobramycin efakwa emthanjeni;futhi esivivinyweni esisodwa isikhathi kuze kube ukukhushulwa okulandelayo kwakungehlukile.Ayikho imiphumela emibi ebalulekile ebikiwe.Kunobufakazi obuncane obuwusizo bezinga eliphezulu lokwahlulela ukuphumelela kwemithi elwa namagciwane ehogelwe ekwelapheni ukukhushulwa kwamaphaphu kubantu abane-cystic fibrosis.Izivivinyo ezifakiwe azizange zinikezwe amandla anele ukufeza izinhloso zazo.Ngakho-ke, asikwazi ukubonisa ukuthi ukwelashwa okuthile bekuphakeme kunokunye noma cha.Ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuthi i-tobramycin ehogelwe ingasetshenziswa yini njengenye indawo ye-tobramycin efakwa emthanjeni ngenxa yokwanda kwamaphaphu.