Imikhiqizo

I-Trans-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid iyinhlanganisela yamakhemikhali enezinto ezingase zisetshenziswe emkhakheni we-organic synthesis kanye nocwaningo lwezemithi.Kubonakala ngokuba khona kweringi ye-pyrrolidine esikhundleni seqembu elivikelayo le-tert-butoxycarbonyl (Boc) ku-athomu ye-nitrogen kanye neqembu le-trifluoromethyl eringini ye-phenyl.Okunye kokusetshenziswa okubalulekile kwe-trans-1-(tert-Butoxycarbonyl)- I-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid injengemaphakathi ekuhlanganiseni ezinye izinhlanganisela eziphilayo.Isakhiwo sawo esiyingqayizivele kanye namaqembu asebenzayo akwenza kube isisekelo sokwakha izinto ezihlukahlukene zokwakha ama-molecule ayinkimbinkimbi.Iqembu le-Boc lisebenza njengeqembu elivikelayo, elingasuswa ngokukhetha ngaphansi kwezimo ezithile zokusabela ukuze liveze isayithi elisebenzayo ukuze lilungiswe okwengeziwe.Lokhu kuvumela ukuguqulwa kwezinto eziphilayo ezilawulwayo nezinembile.Iqembu le-trifluoromethyl ku-trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid liphinde linikeze izici ezibalulekile kanye nezicelo ezingase zibe khona.Amaqembu e-Trifluoromethyl aziwa ngobunjalo bawo bokuhoxiswa kwe-electron kanye ne-lipophilicity, engathuthukisa amandla, ukuqina kwe-metabolic, kanye nokuba khona kwe-bioavailability yabafuna izidakamizwa.Ukwengeza, iqembu le-trifluoromethyl lingakwazi ukulinganisa izici ze-physicochemical ze-compound, ezithinta ukuncibilika, i-lipophilicity, kanye ne-receptor ebopha ubuhlobo. I-carboxylic acid ingase ibonise umsebenzi webhayoloji ngokwayo noma njenge-prodrug.Izidakamizwa ziyizinhlanganisela ezingasebenzi ngokwebhayoloji ezishintshashintsha amakhemikhali noma ama-enzymatic emzimbeni ukuze ziguqulwe zibe izidakamizwa ezisebenzayo.Kwezinye izimo, iqembu elivikelayo le-Boc lingasuswa ngokukhetha ku-vivo, kusebenze inhlanganisela ukuze kutholwe umphumela wokwelapha ofunekayo.Ngenkathi izinhlelo zokusebenza ezithile nokusetshenziswa okungase kube khona kwe-trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl) phenyl)pyrrolidine-3-carboxylic acid maningi, uphenyo oluqhubekayo nocwaningo kuyadingeka ukuze kuhlolwe amandla ayo aphelele.Lokhu ngokuvamile kuhilela ukulungiselelwa kwamakhemikhali ezokwelapha, izifundo zobudlelwane besakhiwo nomsebenzi, nokuhlolwa kwezinto eziphilayo.Ngokuziqonda kahle izici zenhlanganisela nokusebenza kabusha, ososayensi bangahlola ukufaneleka kwayo ukukhomba izifo noma izimo ezithile, okuholela ekuthuthukisweni kwabantu abasha bezidakamizwa noma ama-catalytic agents esikhathini esizayo.