Urease CAS:9002-13-5
| Inombolo Yekhathalogi | XD90388 |
| Igama Lomkhiqizo | Urease |
| I-CAS | 9002-13-5 |
| I-Molecular Formula | N/A |
| Isisindo samangqamuzana | - |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 35079090 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | Impushana emhlophe |
I-Nickel iyisihlonzi se-virulence ye-pathogen yesisu somuntu i-Helicobacter pylori.Ngempela, i-H. pylori inama-nickel-enzymes amabili abalulekile ku-vivo colonization, i- [NiFe] hydrogenase ne-urease, i-virulence factor eningi equkethe ama-nickel ion angama-24 ngenkimbinkimbi ngayinye esebenzayo.Ngenxa yalawa ma-enzyme amabili, ukusinda kwe-H. pylori kuncike ekutholakaleni okubalulekile kwe-nickel, okusho ukulawula okuqinile kokusatshalaliswa nokugcinwa kwayo.Kulesi sibuyekezo, sizokwethula izindlela zokwenza kusebenze ama-enzyme e-nickel kanye nezindlela zangempela ezitholakala ku-H. pylori ukuze kuthathwe, ukushushumbiswa nokusabalalisa i-nickel phakathi kwama-enzyme amabili.Lokhu kufaka (i) isistimu yokuthatha i-nickel yangaphandle, isithuthi esincike ku-FrpB4 TonB, (ii) amaphrotheni agqagqene kanye namanethiwekhi okusebenzisana abandakanyeka ekuhwebeni nasekusabalaliseni i-nickel phakathi kwe-urease ne-hydrogenase kanye, (iii) ne-Helicobacter ethize yamaphrotheni abopha i-nickel. ababambe iqhaza ekugcinweni kwe-nickel futhi bangadlala indima ye-metallo-chaperones.Okokugcina, sizoxoxa ngomthelela wozakwethu bokushushumbiswa kwe-nickel ku-virulence futhi sibaphakamise njengemigomo emisha yokwelapha yokwelapha ngokumelene nokutheleleka kwe-H. pylori.
