I-Uridine-5'-diphosphoglucuronic acid trisodium usawoti CAS:63700-19-6 Impuphu emhlophe
| Inombolo Yekhathalogi | XD90382 |
| Igama Lomkhiqizo | Uridine-5'-diphosphoglucuronic acid trisodium usawoti |
| I-CAS | 63700-19-6 |
| I-Molecular Formula | I-C15H19N2O18P2Na3 |
| Isisindo samangqamuzana | 646.20 |
| Imininingwane Yesitoreji | <-4 °C |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | Impushana emhlophe |
Ucwaningo lwamanje luhlose ukuphenya umthelela wobuthi be-irinotecan nge-biotransformation ye-glucoaurantio-obtusin kuya ku-aurantio-obtusin.Ukuphathwa kwe-intraperitoneal (ip) ka-100 mg/kg i-aurantio-obtusin kwandisa kakhulu ubuthi be-irinotecan, kodwa ukulawulwa kwe-ip kwe-100 mg/kg i-glucoaurantio-obtusin kubonise umthelela onganaki maqondana nobuthi be-irinotecan.Ngaphezu kwalokho, umshini wachazwa ngokunquma amandla okuvimbela e-glucoaurantio-obtusin kanye ne-aurantio-obtusin maqondana ne-glucuronidation metabolism ye-SN-38 ethathwe njengomkhiqizo omkhulu osebenzayo obhekele ubuthi be-irinotecan.Imiphumela yabonisa ukuthi i-aurantio-obtusin ibonise ukuvinjelwa okunamandla kokuncintisana maqondana ne-glucuronidation ye-SN-38, kodwa amandla okuvimbela angenakuqhathaniswa e-glucoaurantio-obtusin ebheke ku-SN-38 glucuronidation abonwa.Le miphumela ibonise ukuthi i-biotransformation ye-glucoaurantio-obtusin ibheke ku-aurantio-obtusin ikhuphule ubuthi be-irinotecan ngokuvimbela okukhulayo kwe-SN-38 glucuronidation.
