I-Vancomycin hydrochloride Cas: 1404-93-9 Imhlophe cishe imhlophe noma i-tan kuya kumpushana opinki
| Inombolo Yekhathalogi | I-XD90197 |
| Igama Lomkhiqizo | I-Vancomycin hydrochloride |
| I-CAS | 1404-93-9 |
| I-Molecular Formula | I-C66H76Cl3N9O24 |
| Isisindo samangqamuzana | 1485.7145 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| Amanzi | I-NMT 5.0% |
| Izinsimbi ezinzima | I-NMT 30ppm |
| pH | 2.5 - 4.5 |
| Ama-bacterium endotoxins | I-NMT 0.33EU/mg ye-Vancomycin |
| Ukucaca Kwesixazululo | Kucace |
| Ukubukeka | Imhlophe, icishe ibe mhlophe, noma i-tan to pink powder |
| Vancomycin B | I-NLT 85% |
| Umkhawulo we-monodechlorovancomycin | I-NMT 4.7% |
| I-Assay (microbial, anhydrous basis) | I-NLT 900ug/mg |
1.Izehlakalo zokutheleleka kwe-Staphylococcus aureus ezitholwa umphakathi ezitholakala emphakathini zikhuphuka ngesivinini esishaqisayo.Ukwelashwa okuphumelelayo ngokomlando bekuhilela ukukhishwa kwangaphambi kwesikhathi kanye nokuphathwa kwama-antibiotic.Lolu cwaningo lwenzelwe ukuhlonza ukusebenza ngempumelelo kokwelashwa okunamandla ekwelapheni izifo zezandla.Uhlolo olungahleliwe olulindelwe lwenziwa esibhedlela sesifunda se-level I.Iziguli ezinokutheleleka kwezandla zithole i-empiric intravenous vancomycin lapho zilaliswa khona noma nge-intravenous cefazolin.Imiphumela yalandelelwa kusetshenziswa ubunzima bokutheleleka, impendulo efanele yomtholampilo, kanye nobude besikhathi sokuhlala.Ukusebenza kahle kwezindleko kubalwe kusetshenziswa izindleko eziphelele zesiguli ngasinye kuwo womabili amaqembu.Ukuhlaziywa kwezibalo kwenziwa.Iziguli ezingamashumi amane nesithupha zabhaliswa ocwaningweni.Amashumi amabili nane afakwe ngokungahleliwe ku-cefazolin (amaphesenti angu-52.2) kanye nama-22 (amaphesenti angu-47.8) e-vancomycin.Kwakungekho umehluko wezibalo phakathi kwezindleko zokwelashwa (p <0.20) noma ubude besilinganiso sokuhlala (p <0.18) phakathi kwamaqembu.Iziguli ezingahleliwe ku-cefazolin zinezindleko eziphakeme zokwelashwa uma kuqhathaniswa neziguli ezingahleliwe ku-vancomycin (p <0.05).Iziguli ezinezifo ezinzima kakhulu zinezindleko ezibiza kakhulu zokwelapha (p <0.0001) kanye nobude besilinganiso sokuhlala isikhathi eside (p = 0.0002).Ngasekupheleni kocwaningo, izehlakalo ze-S. aureus emelana ne-methicillin etholwe ngumphakathi esibhedlela sesifunda sababhali zitholakale zingamaphesenti angama-72, okudale ukuthi ucwaningo lunqanyulwe ngaphambi kwesikhathi yibhodi lokubuyekeza lesikhungo ngenxa yezigameko eziningi. ngaphandle kokungahleliwe okwengeziwe.Ukwelashwa kwangaphambi kwesikhathi okufanelekile kwe-S. aureus emelana ne-methicillin akukaqinisekiswa ngokuqinisekile.Awukho umehluko emphumeleni wokusetshenziswa kwe-cefazolin ngokumelene ne-vancomycin njenge-ejenti yomugqa wokuqala ohlonziwe.
2.Ngokuthuthukiswa kokuphulukiswa kwesilonda ngokusebenzisa ama-antibiotic e-prophylactic emithanjeni kanye nokulungiswa kwezobuchwepheshe, izifo zendololwane zangemva kokuhlinzwa ziye zaba kancane kodwa zisenzeka ekuhlinzeni indololwane okukhethekile.Inhloso yalolu cwaningo bekuwukuhlola ukuphepha kanye nempumelelo kokufakwa kwe-vancomycin kwe-prophylactic endaweni yokuhlinzwa ukuze kwehliswe izehlakalo zokutheleleka ngemva kokukhululwa kwezindololwane eziqinile zangemva kwesigameko. isikhathi senziwe.Eqenjini lokulawula (iziguli ze-93), i-prophylaxis elula ene-antibiotic ejwayelekile ye-intravenous yenziwa;eqenjini le-vancomycin (iziguli ezingu-179), i-vancomycin powder yafakwa ngqo esilondeni ngaphambi kokuvalwa kanye ne-standard intravenous prophylaxis.Ngemva kokulandelela okungenani izinyanga ezingu-6, iqembu lokulawula litholakale linezifo ezingu-6 (6.45%; ukuzethemba isikhawu: 2.40% -13.52%) uma kuqhathaniswa nokungekho (0%; isikhathi sokuzethemba: 0-2%.04%) eqenjini le-vancom ycin, okwakungumehluko obalulekile ngokwezibalo (P = .0027).Ayikho imiphumela emibi eyabhalwa ekusetshenzisweni okuqondile kwe-vancomycin powder.Ukusetshenziswa kwendawo kwe-vancomycin powder kungase kube indlela ethembisayo yokuvimbela ukutheleleka kwe-elbow ngemuva kokukhishwa kwe-elbow ezigulini ezinobunzima be-elbow post-traumatic.
