(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone CAS: 915095-86-2
| Inombolo Yekhathalogi | XD93369 |
| Igama Lomkhiqizo | (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone |
| I-CAS | 915095-86-2 |
| Ifomu le-Molecularla | I-C13H7ClFIO |
| Isisindo samangqamuzana | 360.55 |
| Imininingwane Yesitoreji | I-ambient |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| U-Asay | 99% iminithi |
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone, eyaziwa nangokuthi i-CF12, iyinhlanganisela yekhemikhali enezinhlelo ezahlukene ocwaningweni lwezemithi kanye nokuhlanganisa.Okunye ukusetshenziswa okuyinhloko kwe-CF12 kulele endimeni yayo njengebhulokhi yokwakha ehlukahlukene. noma okuphakathi ukuze kuhlanganiswe izinhlanganisela zezinto eziphilayo eziyinkimbinkimbi.I-CF12 iqukethe amaqembu asebenzayo afana ne-chloro ne-fluoro substituent, engashintshwa ukuze ethule amanye amaqembu afiswayo noma ukuguqulwa kwesakhiwo.Lokhu kuvumela osokhemisi ukuba benze ngendlela oyifisayo izakhiwo zenhlanganisela futhi bathuthukise izici zayo zemithi yezinhlelo zokusebenza ezithile.CF12 ibonise amandla ekuthuthukisweni kwamakhandidethi ezidakamizwa ezinhlobonhlobo zezindawo zokwelapha.Isibonelo, ukuba khona kwe-chloro ne-fluoro esikhundleni se-CF12 kungakhuphula i-lipophilicity ye-compound, engathuthukisa ikhono layo lokungena kulwelwesi lwebhayoloji futhi ithuthukise ukumuncwa kwezidakamizwa.Lesi sakhiwo sithandeka kakhulu ekwakhiweni kwemithi elawulwa ngomlomo. Ngaphezu kwalokho, izici zesakhiwo ze-CF12 ziyenza ibe ikhandidethi elithakazelisayo lokuhlola amandla ayo njenge-ejenti elwa namagciwane.Inhlanganisela yale nhlanganisela yezinto ezithatha indawo ze-halogen ikhonjiswe ukuthi ibonisa umsebenzi we-antimicrobial obanzi ngokumelene nezinhlobo ezihlukahlukene zamagciwane kanye nesikhunta.Lokhu kuvula amathuba okuthi i-CF12 iphenywe ukuze kuthuthukiswe ama-antibiotics anoveli noma imishanguzo ye-antifungal.Ngaphezu kwalokho, i-CF12 itholakale inemisebenzi ethile yebhayoloji eyenza ibe ikhandidethi elifaneleka kwezinye izinhlelo zokusebenza zokwelapha.Ucwaningo luye lwabonisa ukuthi i-CF12 ibonisa izakhiwo ezibalulekile zokulwa nokuvuvukala, okungenzeka iyenze ibe yigugu ekwelapheni izifo ezibonakala ngokuvuvukala, njengezifo ezizimele noma izimo ezingapheli zokuvuvukala. Nakuba i-CF12 ibonisa isithembiso kulezi zindawo ezihlukahlukene, kubalulekile ukuqaphela ukuthi ucwaningo nentuthuko kuyadingeka ukuze uqonde ngokugcwele amandla ayo njengomuntu ozokhethwa ezidakamizwa.Ucwaningo olubanzi lwe-preclinical, okuhlanganisa ukuhlolwa kwe-in vitro kanye ne-vivo, kuyadingeka ukuze kuhlolwe ukusebenza kahle kwe-CF12, izakhiwo ze-pharmacokinetic, kanye nephrofayili yokuphepha.Ngaphezu kwalokho, ukuthuthukiswa kwesakhiwo samakhemikhali e-CF12 kanye nokuhlolwa komsebenzi wayo ngokumelene nemigomo ethile yesifo kuyadingeka ukuze kuvulwe amandla ayo aphelele okwelapha. kunesithembiso socwaningo lwezemithi kanye nokuhlanganisa.Ukuguquguquka kwayo njengesakhiwo sokwakha kuvumela ukwakhiwa kwezinhlanganisela eziyinkimbinkimbi zezinto eziphilayo, kuyilapho izici zayo zemithi ezifana ne-lipophilicity kanye nomsebenzi we-antimicrobial zenza kube umuntu ongase abe yikhandidethi ekuthuthukisweni kwezidakamizwa ezindaweni ezifana nama-antibiotics, ama-antifungal, nama-anti-inflammatory agents.Kodwa-ke, kusadingeka ucwaningo olubanzi ukuze kuhlolwe ngokugcwele amandla ayo okwelapha futhi kunqunywe ukusebenza kwawo njengomuntu oqokelwe umuthi.
