Imikhiqizo

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, eyaziwa nangokuthi i-CF3-112, iyinhlanganisela yamakhemikhali enezinhlelo ezimbalwa ezibalulekile emkhakheni wamakhemikhali okwelapha kanye nezidakamizwa. ukuthuthukiswa.Okunye ukusetshenziswa okukhulu kwe-CF3-112 njenge-kinase inhibitor.Ama-Kinase ama-enzyme alawula izinqubo ezihlukahlukene zamaselula emzimbeni, okuhlanganisa ukukhula kwamangqamuzana, ukuhlukana, nokuxhumana.Ukungasebenzi kahle kwe-kinases kuvame ukuhlotshaniswa nezifo ezinjengomdlavuza kanye nokuphazamiseka kwe-autoimmune.I-CF3-112 itholakale ibonisa umsebenzi onamandla okuvimbela ama-kinase athile, okuyenza ibe ikhandidethi elithembisayo lokuthuthukiswa kwezindlela zokwelapha ezihlosiwe.Ikakhulukazi, i-CF3-112 ibonise umsebenzi ovimbelayo ngokumelene ne-Aurora kinases, edlala indima ebalulekile ekuhlukaniseni amaseli kanye bavame ukuvezwa ngokweqile kumaseli omdlavuza.Ngokuqondisa ngokukhetha nokuvimbela lawa ma-kinase, i-CF3-112 ingasiza ekumiseni ukwanda okusheshayo kwamangqamuzana omdlavuza futhi okungenzeka inikeze inzuzo yokwelapha.Ngaphezu kwalokho, i-CF3-112 ibonise umsebenzi omelene namanye ama-kinase afana ne-FLT3 ne-JAK2, afakwe ku-hematological. ama-malignancies afana ne-acute myeloid leukemia (AML) kanye ne-myeloproliferative neoplasms.Ukuvimbela la ma-kinase nge-CF3-112 kunamandla okuphazamisa izindlela zokubonisa eziqhuba ukukhula nokusinda kwamangqamuzana omdlavuza, okuhlinzeka ngamathuba amasha okwelashwa kwalezi zifo.Ngaphezu komsebenzi wayo we-kinase inhibitory, i-CF3-112 ingase ibe ne-anti -imiphumela yokuvuvukala.Ukuvuvukala kuyimpendulo eyinkimbinkimbi yebhayoloji edlala indima ezifweni eziningi, okubandakanya ukuphazamiseka kwe-autoimmune kanye nezimo ezingapheli zokuvuvukala.I-CF3-112 ibonise isithembiso njengesivimbeli sezindlela ezithile zokuvuvukala, okungenzeka inikeze indlela yokwelapha yokuphatha lezi zimo.Nakuba i-CF3-112 inamandla amakhulu, kubalulekile ukuqaphela ukuthi ucwaningo olwengeziwe kanye nentuthuko kuyadingeka ukuze uqonde ngokugcwele ukusebenza kwayo, ukuphepha. iphrofayili, kanye nohlelo lokusebenza olulungile.Njenganoma iyiphi inhlanganisela, ukuhlolwa okuqinile kanye nezifundo zangaphambi komtholampilo kuyadingeka ngaphambi kokuba kuthuthukele ekuhlolweni komtholampilo kwabantu.Umsebenzi wayo we-kinase inhibitory, ikakhulukazi ngokumelene ne-Aurora kinases, FLT3, kanye ne-JAK2, uyibeka njengekhandidethi elingase libe khona ekuthuthukisweni kwezindlela zokwelapha ezihlosiwe zomdlavuza kanye ne-hematological malignancies.Izakhiwo zayo zokulwa nokuvuvukala futhi ziphakamisa izinhlelo zokusebenza ezingase zibe khona ekulawuleni ukuphazamiseka kwe-autoimmune kanye nezimo ezingapheli zokuvuvukala.Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze uvule amandla alo aphelele okwelapha nokuhlola ukuphepha nokusebenza kwawo.