2′-Deoxyuridine Cas:951-78-0
| Inombolo Yekhathalogi | XD90583 |
| Igama Lomkhiqizo | 2'-Deoxyuridine |
| I-CAS | 951-78-0 |
| I-Molecular Formula | I-C9H12N2O5 |
| Isisindo samangqamuzana | 228.20 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe ukuya kokumhlophe |
| Isivivinyo | 99% |
| I-Melting Point | 164 - 168 Deg C |
| Ukulahlekelwa Ekumisweni | <1.0% |
| Izinsalela ekushiseni | <0.1% |
Ukusetshenziswa okungcono kwe-nitrogen ezinkomeni kubalulekile ukuze kuvikeleke ukukhiqizwa kwezinkomo okuqhubekayo.Njengoba ama-purines nama-pyrimidines (PP) enza ingxenye encomekayo ye-rumen nitrogen, ukuqonda okuthuthukisiwe kokumuncwa kanye nokuphakathi kwe-metabolism ye-PP kubalulekile.Umsebenzi wamanje uchaza ukuthuthukiswa nokuqinisekiswa kwendlela ebucayi neqondile yokunqunywa kanyekanye kwama-purines angama-20 (adenine, guanine, guanosine, inosine, 2'-deoxyguanosine, 2'-deoxyinosine, xanthine, hypoxanthine), pyrimidines (cytosine, thymine, uracil, cytidine, uridine, thymidine, 2'-deoxyuridine), kanye nemikhiqizo yabo yokuwohloka (i-uric acid, i-allantoin, i-β-alanine, i-β-ureidopropionic acid, i-β-aminoisobutyric acid) ku-plasma yegazi lezinkomo zobisi.Indlela yokusebenza ephezulu esekelwe ku-chromatography yoketshezi ehlanganiswe ne-electrospray ionization tandem mass spectrometry (LC-MS/MS) yahlanganiswa namazinga okulinganisa okumataniswa kwe-matrix ngayinye kanye nezinhlanganisela zereferensi eziqinile ezilebulwe nge-isotopically.Ukuhlaziywa komthamo kwandulelwe inqubo inoveli yokwelashwa kwangaphambili ehlanganisa imvula ye-ethanol, ukuhlunga, ukuhwamuka kanye nokwakhiwa kabusha.Amapharamitha okuhlukaniswa nokutholwa ngesikhathi sokuhlaziywa kwe-LC-MS/MS aphenywa.Kwaqinisekiswa ukuthi ukusebenzisa imodeli yokulinganisa ilogu kunemodeli yokulinganisa yomugqa kuholele ekwehleni kwe-CV% kanye nokuntuleka kokuhlolwa kokufaneleka kubonise ukuhlehla komugqa okwanelisayo.Indlela ihlanganisa izigaba zokuhlushwa ze-metabolite ngayinye ngokwalokho kumasampuli wangempela, isb i-guanine: 0.10-5.0 μmol/L, kanye ne-allantoin: 120-500 μmol/L.I-CV% yezigaba zokulinganisa ezikhethiwe yayingaphansi kwama-25%.Indlela inokuphinda okuhle (i-CV%≤25%) nokunemba okumaphakathi (CV%≤25%) kanye nokululama okuhle kakhulu (91-107%).Wonke ama-metabolites abonise ukuzinza okuhle kwesikhathi eside kanye nokuzinza okuhle ngaphakathi kokugijima (CV%≤10%).Amazinga ahlukene wemiphumela ye-matrix ephelele abonwa ku-plasma, umchamo nobisi.Ukunqunywa kwemiphumela ye-matrix ehlobene kwembula ukuthi le ndlela yayifanele cishe wonke ama-metabolites e-PP ahloliwe ku-plasma athathwe emithanjeni ye-artery kanye ne-portal hepatic, hepatic kanye ne-gastrosplenic veins futhi, ngaphandle kokumbalwa, nakwezinye izinhlobo zezilwane ezinjengenkukhu, ingulube, i-mink, yomuntu kanye negundane.
