I-Adenosine 5'-monophosphate disodium usawoti Cas:4578-31-8
| Inombolo Yekhathalogi | XD90587 |
| Igama Lomkhiqizo | I-Adenosine 5'-monophosphate disodium usawoti |
| I-CAS | 4578-31-8 |
| I-Molecular Formula | I-C10H12N5Na2O7P |
| Isisindo samangqamuzana | 391.18 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe noma evaliwe |
| Isivivinyo | 99% |
| Izinsimbi ezinzima | <10ppm |
| Izinga Lokushisa Lokugcina | +20 ° C |
| Okuqukethwe Amanzi | <26.0% |
Ukuqapha i-pharmacodynamics ngaphezu kwe-pharmacokinetics kungenye yezindlela zokuhlukanisa ukwelashwa kwe-mycophenolate mofetil.Inhloso yalolu cwaningo kwakuwukusungula izindlela ezibucayi ze-liquid chromatography-tandem mass spectrometry (LC-MS/MS) zokuhlolwa kwe-pharmacokinetics kanye ne-pharmacodynamics ye-mycophenolic acid (MPA).Ukugxiliswa kwe-mycophenolic acid glucuronide (MPAG), i-mycophenolic acid acyl-glucuronide, kanye ne-MPA engaboshiwe kanye ne-MPAG, kwanqunywa, futhi umsebenzi we-inosine-5'-monophosphate dehydrogenase ubalwe ngokulinganisa ukugxila kwe-xanthosine-5'-monophosphate ekhiqizwayo (XMP). ) kanye ne-intracellular adenosine-5'-monophosphate ngemva kokufakwa kwe-peripheral blood mononuclear cell (PBMC) lysates.Ikholomu ye-Metal-free Mastro(TM) namaphethini amabili egrediyenti asetshenzisiwe ukuze kuthuthukiswe umkhawulo wokulinganisa we-XMP ukuya ku-0.1 μM.Ebangeni lokuhlushwa le-MPA lomtholampilo, umugqa wejika lokulinganisa, ukunemba phakathi nezinsuku zangaphakathi kanye nokunemba kwanelisa imihlahlandlela ehlobene ye-US Food and Drug Administration.Ukugxila kwe-MPA ezigulini ze-hematopoietic stem cell transplant (HSCT) ezinqunywe ukuhlolwa kwe-enzyme kanye nendlela yamanje ye-LC-MS/MS ibonise ukuhlobana okuhle (r (2) = 0.95, p <0.001).Kulolu cwaningo, sibika izindlela ezizwelayo neziqinisekisiwe ze-LC-MS/MS zokuhlola i-pharmacokinetics kanye ne-pharmacodynamics ye-MPA, ezwela ngokwanele ukuhlola amanani amancane e-PBMC lysates aqoqwe ngokushesha ngemva kwe-HSCT.
