I-Cytidine Cas: 65-46-3 I-crystalline powder emhlophe 99%
| Inombolo Yekhathalogi | XD90586 |
| Igama Lomkhiqizo | I-Cytidine |
| I-CAS | 65-46-3 |
| I-Molecular Formula | I-C9H13N3O5 |
| Isisindo samangqamuzana | 243.22 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| Isivivinyo | 99% |
| Izinsimbi ezinzima | <20ppm |
| I-Chemical Formula | I-C9H13N3O5 |
| Ukulahlekelwa Ekumisweni | <0.5 % |
| Izinsalela ekushiseni | <0.10 % |
Ukunikezwa kwamaselula kwe-deoxynucleoside triphosphates (dNTPs) kubalulekile ekuphindaphindeni nasekulungiseni i-DNA.Kulolu cwaningo, siphenye indima ye-CMP/UMP kinase (CMPK), i-enzyme eyenza ukwakheka kwe-CDP, ekulungiseni i-DNA.Ukwehla kwe-CMPK kubambezela ukulungiswa kwe-DNA ngesikhathi sokululama emonakalweni we-UV kumaseli ancishwe i-serum kodwa hhayi kumaseli angenayo i-serum.Ukunikezwa kwangaphandle kwe-cytidine noma i-deoxycytidine kusiza ukulungiswa kwe-DNA kuncike ku-CMPK kumaseli ancishwe i-serum, okuphakamisa ukuthi ukuhlanganiswa kwe-dCDP noma i-CDP kunquma izinga lokulungisa.Kodwa-ke, ukwehliswa kwe-CMPK akuthinti izinga lesimo esizinzile se-dCTP kumaseli ancishwe i-serum.Sibe sesithola ukwenziwa kwasendaweni kwe-CMPK kumasayithi omonakalo we-DNA kanye nokwakheka kwayo okuyinkimbinkimbi nge-Tip60 kanye ne-ribonucleotide reductase.Ukuhlaziya kwethu kubonise ukuthi i-N-terminal 32-amino-acid ye-CMPK iyadingeka ukuze ibuthelwe kumasayithi onakaliswa kwe-DNA ngendlela encike ku-Tip60.Ukuchazwa kabusha kohlobo lwasendle kodwa hhayi i-N-terminus esusiwe ye-CMPK kubuyisela ukusebenza kahle kokulungisa i-DNA kumaseli e-CMPK.Siphakamise ukuthi ukwakheka kwe-dCDP yesayithi ethile nge-CMPK kunikeze izindlela zokwenza lula ukulungiswa kwe-DNA kumaseli ancishwe i-serum.
