Imikhiqizo

1. Inhloso yalolu cwaningo kwakuwukwenza imodeli elula ye-pharmacokinetic-pharmacodynamic (PK-PD) engabonisa isikhathi esiphelele soshintsho ekubalweni kwe-platelet ukubikezela ukuqala kanye nezinga le-thrombocytopenia, elikhawulela kakhulu ukusetshenziswa kwe-thrombocytopenia. i-anticancer agent 5-fluorouracil (5-FU), kumagundane.2. Izibalo zeplatelet zilinganiswa ngamagundane alandela ukuphathwa kwe-intravenous kwezilinganiso ezihlukahlukene ze-5-FU ngezinsuku ze-4 ukuthola idatha yokuhlaziywa kwemodeli ye-PK-PD.Imodeli yethu ye-PK-PD yayihlanganisa imodeli ye-PK enamagumbi amabili, enamagumbi amathathu emodeli ye-PD kanye namapharamitha angu-10 emodeli ye-PK-PD.3. Ngemva kokwelashwa kwe-5-FU, izibalo zeplatelet zehla kancane zafika ezingeni le-nadir, zabonisa ukuphindaphinda ukuya ngaphezu kwezinga lesisekelo ngaphambi kokubuyela kumazinga ayisisekelo.Izibalo ze-Nadir platelet kanye ne-rebounds zahluka ngezinga le-AUC0-∞.Imodeli yokugcina ye-PK-PD ibonise ngempumelelo idatha yokubalwa kweplatelet kanye nemingcele yokugcina ye-PD yalinganiselwa ngokuqiniseka okukhulu.4. Le modeli ye-PK-PD kanye nokulingiswa kungase kumelele ithuluzi elibalulekile lokulinganisa nokubikezela inkambo yesikhathi esiphelele yoshintsho ekubalweni kwamangqamuzana egazi, futhi kungaba nomthelela ekwakhiweni kwamasu okwelapha nge-5-FU kanye nokuhlolwa kwamanoveli ahlukahlukene e-anticancer agents. okunzima ukuzihlola kubantu.