Imikhiqizo

Inhloso yalolu cwaningo kwakuwukuqhathanisa ukusebenza kahle kwe-valproate ne-haloperidol ekwehliseni izinga lokuyaluza ezigulini ezithintekile emnyangweni wezimo eziphuthumayo.Sabela iziguli ezingu-80 ezicasulwe kakhulu ukuthi zithole i-valproate ye-sodium emthanjeni (20 mg/kg) noma i-haloperidol e-intramuscular (5 mg/1 ml).Ukuyaluza kukalwe ekuqaleni kanye nemizuzu engu-30 ngemva komjovo wokuqala kusetshenziswa I-Agitation-Calmness Evaluation Scale (ACES), i-Positive and Negative Syndrome Scale-Excited Component subscale, kanye ne-Agitated Behavior Scale.Ezigulini ezingama-80 eziphathwe nge-sodium valproate, isilinganiso sesilinganiso se-± SD sasingu-1541.5 ± 286 mg (uhla 940-2400).Isilinganiso se-postintervention ACES scores kusukela kwesisekelo kuya kumaminithi angu-30 ngemva kokujova izidakamizwa kwakuyi-4.73 (SD = 1.93) yeqembu le-valproate kanye ne-5.45 (SD = 2.09) yeqembu le-haloperidol (P = 0.028).Akukho mehluko ophawulekayo obonwe ngokwesilinganiso sezinguquko ze-30 min ngemva kokungenelela kwezikali ezimbili ezengeziwe zokuyaluza.Ingxenye enkulu yeziguli eziseqenjini le-haloperidol yabhekana ne-sedation ejulile (36.2%, P <0.001) kanye nezimpawu ze-extrapyramidal (8.7%, P = 0.007) uma kuqhathaniswa neqembu le-valproate (2.5% ye-sedation eqinile, asikho isiguli sezimpawu ze-extrapyramidal).Okutholakele kusikisela ukuthi esimweni sokusebenza komtholampilo se-psychiatry ephuthumayo, i-valproate emithanjeni iyasebenza njenge-haloperidol ekwehliseni ukuyaluza, ngephrofayili yokuphepha engcono.