I-BETA-NADPH TETRA(CYCLOHEXYLAMMONIUM) SALT Cas: 100929-71-3
| Inombolo Yekhathalogi | XD90431 |
| Igama Lomkhiqizo | I-BETA-NADPH TETRA(CYCLOHEXYLAMMONIUM) SALT |
| I-CAS | 100929-71-3 |
| I-Molecular Formula | C21H30N7O17P3.4[C6H13N] |
| Isisindo samangqamuzana | 1142.11748 |
| Imininingwane Yesitoreji | -20 °C |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| Isivivinyo | 99% |
Ama-oxidase e-NADPH awumndeni wama-enzyme akhiqiza izinhlobo ze-oxygen esebenzayo (ROS).I-NOX1 (NADPH oxidase 1) kanye ne-NOX2 oxidase yimithombo emikhulu ye-ROS odongeni lwe-artery ezimweni ezifana nomfutho wegazi ophakeme, i-hypercholesterolaemia, isifo sikashukela nokuguga, ngakho-ke ingaba negalelo elibalulekile ekucindezelekeni kwe-oxidative, ukungasebenzi kwe-endothelial kanye nokuvuvukala kwemithambo engaphansi. ukuvuselelwa kabusha kwe-arterial kanye ne-atherogenesis.Kulokhu Buyekeza, sithuthukisa umqondo wokuthi uma kuqhathaniswa nokusetshenziswa kwama-antioxidants avamile, ukuvimbela i-NOX1 ne-NOX2 oxidases kuyindlela ephakeme yokulwa nokucindezeleka okwenziwe nge-oxidative.Sichaza kafushane ama-NADPH oxidase inhibitors avamile futhi asafufusayo.Ngaphezu kwalokho, sigqamisa indima ebalulekile ye-NADPH oxidase regulatory subunit, i-p47phox, emsebenzini we-vascular NOX1 kanye ne-NOX2 oxidases, futhi siphakamisa ukuthi ukuqonda kangcono ukusebenzisana kwayo okuqondile kwamangqamuzana kungenza kanjani ukuthuthukiswa kwezidakamizwa ezikhethiwe ze-isoform ukuze kuvinjelwe. noma ukwelapha izifo ze-cardio scular.
