I-D-Mannitol Cas: 69-65-8 96-101.5% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | XD90226 |
| Igama Lomkhiqizo | I-D-Mannitol |
| I-CAS | 69-65-8 |
| I-Molecular Formula | I-C6H14O6 |
| Isisindo samangqamuzana | 182.1718 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29054300 |
Ukucaciswa Komkhiqizo
| I-Melting Point | 164 - 169 Deg C |
| Ibanga | BP |
| Ukuzungezisa okuqondile | +23 - +25 |
| AS | <1ppm |
| Ukulahlekelwa Ekumisweni | <0.3% |
| I-sulfate | <0.01% |
| Isivivinyo | 96 - 101.5% |
| I-Nickel | ≤ 1ppm |
| I-Acid | <0.2ml |
| Ukunciphisa Ushukela | ≤ 0.1% |
| I-Conductivity | ⩽ 20us/cm |
| Cl | <0.007% |
| Ukubukeka | I-crystalline powder emhlophe |
Ukuze siphenye indima yengcindezi ye-oxidative kanye/noma ukukhubazeka kwe-mitochondrial esigamekweni sokulimala kwezinso okukhulu (AKI) phakathi ne-sepsis, sakha imodeli ye-sepsis-induced in vitro sisebenzisa amaseli e-proximal epithelial epithelial avezwe ku-endotoxin yebhaktheriya (lipopolysaccharide, LPS).Lolu phenyo lunikeze izici ezibalulekile ebudlelwaneni phakathi kwengcindezi ye-oxidative kanye nokukhubazeka komsebenzi weketango lokuphefumula le-mitochondrial.Ukwelashwa kwe-LPS kuphumele ekwenyukeni kokuvezwa kwe-inducible nitric oxide synthase (iNOS) ne-NADPH oxidase 4 (NOX-4), okuphakamisa ukuveza ngokweqile kwe-cytosolic kwe-nitric oxide ne-superoxide anion, uhlobo oluyinhloko lwe-nitrogen esebenzayo (RNS) kanye nezinhlobo ze-oxygen esebenzayo. (I-ROS).Lesi simo se-oxidant sibonakale siphazamisa i-mitochondrial oxidative phosphorylation ngokunciphisa umsebenzi we-cytochrome c oxidase.Ngenxa yalokho, ukuphazamiseka ekuthuthweni kwama-electron kanye nokumpompa kwe-proton kulwelwesi lwangaphakathi lwe-mitochondrial kwenzeke, okuholele ekwehleni kwamandla olwelwesi lwe-mitochond rial, ukukhululwa kwezinto ezidala i-apoptotic kanye nokuncipha kwe-adenosine triphosphate.Kuyathakazelisa ukuthi ngemva kokuqondiswa yi-RNS ne-ROS, i-mitochondria yaba ngumkhiqizi we-ROS, ngaleyo ndlela yaba nesandla ekwandiseni ukungasebenzi kahle kwe-mitochondrial.Indima yama-oxidants ekungasebenzi kahle kwe-mitochondrial yabuye yaqinisekiswa ngokusetshenziswa kwe-iNOS inhibitors noma ama-antioxidants agcina umsebenzi we-cytochrome c oxidase futhi avimbele ukushabalala kolwelwesi lwe-mitochondrial okungenzeka.Le miphumela iphakamisa ukuthi i-AKI ebangelwa i-sepsis akufanele nje ibhekwe njengokwehluleka kwesimo samandla kodwa futhi njengempendulo edidiyelwe, okuhlanganisa imicimbi yokuloba, ukusayinda kwe-ROS, umsebenzi we-mitochondrial kanye nokuma kwe-metabolic njenge-apoptosis.
