I-DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS:28718-90-3 99% Impuphu ephuzi
| Inombolo Yekhathalogi | XD90505 |
| Igama Lomkhiqizo | I-DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| I-CAS | 28718-90-3 |
| I-Molecular Formula | I-C16H15N5 · 2HCl |
| Isisindo samangqamuzana | 350.25 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 2933998090 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ephuzi |
| Isivivinyo | 99% iminithi |
| Okokusetshenziswa kocwaningo kuphela, hhayi okomuntu | Ukusetshenziswa kocwaningo kuphela, hhayi ukusetshenziswa komuntu |
I-Melatonin ibandakanyeka emisebenzini eminingi yomzimba, futhi inemiphumela ehlukile ku-apoptosis kumaseli avamile nawomdlavuza.Kodwa-ke, indlela yezindima zayo ze-antitumor ayiqondwa kahle.Kulolu cwaningo, sibonisa ukuthi i-melatonin ithuthukisa i-apoptosis eyenziwe yi-tunicamycin kumaseli e-carcinoma yebele lomuntu MDA-MB-231.I-Melatonin iphakamisa-ilawula iphrotheni ye-pro-apoptotic Bim expression emazingeni okubhalwa phansi lapho kukhona i-tunicamycin.I-Melatonin ivimbela inkulumo ye-COX-2 eyenziwe nge-tunicamycin kumaseli e-MDA-MB-231.Ngaphezu kwalokho, ukuvinjelwa komsebenzi we-COX-2 usebenzisa i-COX-2 inhibitor, NS398, kwandisa i-apoptosis eyenziwe yi-tunicamycin.Kuyathakazelisa ukuthi le miphumela ayizange ihlotshaniswe nezindlela zesignali ye-melatonin receptor.Ubuthi be-Pertussis (i-Gi protein inhibitor evamile) noma i-luzindole (i-melatonin receptor emelene ne-nonspecific) ayizange iwuhlehlise umphumela we-melatonin.Ukwengeza, i-melatonin ivimbe umsebenzi wokuloba we-NF-κB owenziwe yi-tunicamycin, i-p65 nuclear translocation, kanye ne-p38 MAPK act ivation.Ukuvinjelwa kwe-Melatonin-mediated p38 MAPK kube nomthelela ekwehleni kokuqina kwe-COX-2 mRNA.Uma sihlanganiswa, imiphumela yethu iphakamisa ukuthi i-melatonin ithuthukisa ukusebenza kwe-antitumor ngokusebenzisa ukulawulwa okuphezulu kwe-Bim expression kanye nokwehlisa ukulawulwa kwenkulumo ye-COX-2 kumaseli e-MDA-MB-231 aphethwe yi-tunicamycin.
