I-Erythromycin CAS:114-07-8 99% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | XD90353 |
| Igama Lomkhiqizo | I-Erythromycin |
| I-CAS | 114-07-8 |
| I-Molecular Formula | I-C37H67NO13 |
| Isisindo samangqamuzana | 733.93 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29415000 |
Ukucaciswa Komkhiqizo
| Ukuhlonza | Ukuqhathaniswa kokumuncwa kwe-IR ne-USP RS |
| Amanzi | 10% ubuningi |
| I-Ethanol | 0.5% ubuningi |
| Izinsalela ekushiseni | 0.2% ubuningi |
| Isivivinyo | 99% |
| Ukuzungezisa okuqondile | -71 ° kuya -78 ° |
| Ukubukeka | I-crystalline powder emhlophe |
| I-Crystallinity | Ihlangabezana nezidingo |
| I-Erythromycin B | 12.0% ubuningi |
| I-ErythromycinC | 5.0% ubuningi |
| Umkhawulo we-thiocyanate | 0.3% ubuningi |
| I-Propanol | 0.5% ubuningi |
| I-N-butyl acetate | 0.5% ubuningi |
| I-Erythromycin I-enol ether | 0.3% ubuningi |
| Noma yiziphi izinto ezihlobene nomuntu | 3.0% ubuningi |
Ocwaningweni lwamanje, sihlole ukusebenzisana kwama-antimicrobial agents anamamodeli amane e-lipid membrane alingisa ulwelwesi lwamaseli ezincelisayo kanye nolwelwesi lwebhaktheriya e-Gram-positive kanye ne-negative futhi sahlaziya i-kinetics ebophayo sisebenzisa inqubo yethu ye-surface plasmon resonance (SPR).Izici ezikhethiwe neziqondile zokubopha zama-antimicrobial kulwelwesi lwe-lipid zalinganiselwa, futhi imingcele ye-kinetic yahlaziywa ngokusetshenziswa kwemodeli yokusabela yezifunda ezimbili.Ukuhlaziywa okuphindaphindekayo kwe-kinetics ebophayo kwabonwa.I-Vancomyicn, i-teicoplanin, i-erythromycin, ne-linezolid ibonise ukusebenzisana okuncane nezingqimba ezine ze-lipid ohlelweni lwe-SPR.Ngakolunye uhlangothi, ama-analogue e-vancomycin abonise ukusebenzisana nolwelwesi lwe-lipid oluyimodeli ohlelweni lwe-SPR.Izici ezikhethiwe neziqondile zokubopha zama-analogue e-vancomycin kulwelwesi lwe-lipid kuxoxwa ngalo ngokusekelwe kudatha yemisebenzi ye-in vitro elwa namagciwane kanye nedatha yethu mayelana nesibopho esibophezelayo se-D-alanyl-D-ala ye-terminus eyisishiyagalolunye yodonga lweseli ye-pentapeptide etholwe yi-SPR.Indlela yokusebenza kwe-antibacterial ngokumelene ne-Staphylococcus aureus kanye ne-enterococci engazweli i-vancomycin ingase ihlolwe kusetshenziswa ukuhlangana okubophayo okutholwe nezindlela zethu ze-SPR.Imiphumela ibonisa ukuthi indlela ye-SPR ingasetshenziswa kabanzi ukuze kubikezelwe izici ezibophayo, njengokukhetha nokucaciswa, kwama-antimicrobial agents amaningi kulwelwesi lwe-lipid.
