Imikhiqizo

Ukuze kutholwe ukuqonda mayelana nokuguquguquka kwe-mast cell subpopulations esikhumbeni esivamile nesigulayo, kwasetshenziswa inoveli ye-enzyme-histochemical indlela yokwenza amabala aphindwe kathathu evumela ukutholwa kwe-metachromasia (i-toluidine eluhlaza okwesibhakabhaka) kanye ne-mast cell proteases tryptase ne-chymase ngaphakathi iseli efanayo.Izingxenye ze-Cryostat zisetshenziswe kuma-biopsies esikhumba avela kuzibonelo ezilandelayo: isikhumba esivamile (N = 4), i-psoriasis (N = 13), i-atopic eczema (N = 7), i-lichen planus (N = 6), i-interferon alpha 2a izindawo zokujova (N = 1) ye-leukemic engena futhi ehambisana nesikhumba esivamile sesiguli esifanayo ngaphambi nangemva kokwelashwa.(i) Izinombolo ezilinganayo zamaseli e-tryptase- ne-chymase-positive mast (MCTC) atholwe kuzo zonke izibonelo ezivamile nezinesifo ku-papillary kanye ne-reticular dermis, ngokukhuphuka okuphindwe kathathu kuma-appendages.(ii) Amangqamuzana e-tryptase-positive mast (MCT) ayengekho esikhumbeni esivamile, kodwa aye anda ngokuphawulekayo iphethini ethile yesifo ngaphakathi kwesikhumba se-papillary, i-infiltrate evuthayo kanye nama-appendages azungezile.(iii) Ukwenyuka okuphawulekayo kwe-MCT kuphinde kwaphawulwa ezindaweni zokujova i-interferon ngaphakathi kwe-leukemic infiltrate, kodwa hhayi esikhumbeni esivamile sesiguli esifanayo.Le datha iphakamisa ukuthi i-mast cell dynamics encike esifweni ihilela i-MCT kuphela ekuvuvukeni kwesikhumba nokuthi izinombolo ze-MCT zilawulwa izici zethishu zendawo ezihlukile, eziqondene nezifo.