I-Fluorescein 5-Isothiocyanate (i-isomer I) CAS:3326-32-7
| Inombolo Yekhathalogi | XD90514 |
| Igama Lomkhiqizo | I-Fluorescein 5-Isothiocyanate (i-isomer I) |
| I-CAS | 3326-32-7 |
| I-Molecular Formula | I-C21H11NO5S |
| Isisindo samangqamuzana | 389.38 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ephuzi ekhanyayo |
| Isivivinyo | 99% |
I-Ischemic stroke iboniswe ukuthi idala i-hypermetabolism ye-glucose ku-ischemic penumbra.Idatha yokuhlola neyomtholampilo ikhombisa ukuthi i-infarct-systemic hyperglycemia iyimpoqo engaba khona yokwelapha lapho kushaywa unhlangothi.Kodwa-ke, izifundo zomtholampilo ezihloselwe ukulawulwa kwe-glucose ku-acute stroke azizange zithuthukise umphumela wokusebenza noma zinciphise ukufa.Ngakho, izifundo ezengeziwe mayelana ne-glucose metabolism ebuchosheni be-ischemic ziqinisekisiwe.Sisebenzise imodeli yegundane ye-stroke egcina ukugeleza kwesibambiso.Izilwane zahlaziywa nge- [2-(18)F]-2-fluoro-2-deoxy-d-glucose positron emission tomography noma imaging resonance magnetic phakathi nemizuzu engu-90 yokuvaleka komthambo wobuchopho ophakathi nendawo nangemizuzu engu-60 ngemva kokuphinda kufakwe kabusha.Imiphumela yayihlotshaniswa nokubonwa kwe-resonance kazibuthe yokugeleza kwegazi lobuchopho, ukusakazeka kwamanzi, ukwakheka kwe-lactate, kanye nedatha ye-histological yokufa kweseli kanye nokuwohloka kwesithiyo segazi nobuchopho.Sithole ukwanda [2-(18)F] -2-fluoro-2 -i-deoxy-d-glucose ithatha ngaphakathi kwe-ischemic re gions enqotshwa i-infarction kanye nesifunda se-peri-infarct.I-imaging resonance magnetic yembula ukonakala kokugeleza kwegazi kumazinga e-ischemic ku-infarct kanye nokuncipha kokugeleza kwegazi lobuchopho esifundeni se-peri-infarct.I-spectroscopy ye-magnetic resonance yembula i-lactate endaweni ye-ischemic kanye nokungabikho kwe-lactate endaweni ye-peri-infarct.Ukuhlaziywa kwe-Immunohistochemical kwembule i-apoptosis kanye nokuwohloka kwesithiyo segazi nobuchopho ngaphakathi kwe-infarct.Ukwenyuka kokuthathwa kwe- [2-(18)F]-2-fluoro-2-deoxy-d-glucose ku-cerebral ischemia cishe kukhombisa i-hypermetabolism yokuhlangana noshukela anda amandla. Izidingo zezicubu zobuchopho ze-ischemic kanye ne-hypoperfused, futhi kwenzeka ngaphansi kokubili izimo ze-anaerobic kanye ne-aerobic zikalwa ngokukhiqizwa kwe-lactate yendawo.I-Hyperglycemia ehlobene ne-infarct ehlobene ne-infarct ingasiza ukusiza ukutholakala kweglucose ebuchosheni be-ischemic.Ukulawulwa kwe-glycemic ngokwelashwa kwe-insulin kungaba nomthelela omubi kule nqubo.
