I-Gentamycin Sulfate CAS:1405-41-0 Impuphu emhlophe
| Inombolo Yekhathalogi | XD90364 |
| Igama Lomkhiqizo | I-Gentamycin sulfate |
| I-CAS | 1405-41-0 |
| I-Molecular Formula | I-C21H43N5O7H2So4 |
| Isisindo samangqamuzana | 575.68 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| Amanzi | 15% ubuningi |
| pH | 3.5-5.5 |
| Isivivinyo | 590IU/mg iminithi |
| Ukuzungezisa okuqondile | +107° ukuze +121° |
| Ukubukeka | Impushana emhlophe |
| I-Sulfate (SO4) | 32 - 35% |
| Umlotha one-sulfate | <1.0% |
Ukulimala komgogodla okuphazamisayo kuyinkimbinkimbi ngenxa yokulahlekelwa ukubambezeleka kwama-oligodendrocyte, okuholela ekuqothulweni okungapheli okuqhubekayo.Ngakho-ke, amasu okufakelwa ukuze anikeze amangqamuzana omugqa we-oligodendrocyte kanye nokuthuthukisa izinga le-myelination abonakala efanelekile ukulungiswa kwentambo yomgogodla.Ucwaningo lwamanje luphenye ukuthi ukufakelwa kabusha kwe-human neural stem cell (NSCs) kuguqulwe izakhi zofuzo ukuze kuveze i-Olig2 transcription factor, umlawuli obalulekile wokuthuthukiswa kwe-oligodendrocyte, kungathuthukisa ukutakula kwe-locomotor futhi kuthuthukise i-myelination kumodeli yokulimala komgogodla wegundane.HB1.F3 (F3) ) ulayini we-NSC womuntu ongafi wadluliselwa nge-retroviral vector encoding Olig2, isilawuli esibalulekile sokuthuthukiswa kwe-oligodendrocyte.Ukweqiwa ngokweqile kwe-Olig2 kuma-NSCs womuntu (F3.Olig2) kubangele ukusebenza kwe-NKX2.2 futhi kuqondise ukuhlukaniswa kwama-NSC kumaseli womugqa we-oligodendrocyte in vitro.Ukwethulwa kwe-Olig2 kunikeze umsebenzi okhulayo ophezulu, futhi inombolo enkulu kakhulu ye-F3.Olig2 NSCs itholwe ngamaviki angu-7 ngemva kokufakelwa entanjeni yomgogodla ephazamisekile kunaleyo ye-F3 NSCs yabazali.Ama-NSC e-F3.Olig2 abonise ukufuduka okuvamisile kundaba emhlophe, kuyilapho ama-F3 NSC ngokuvamile evalelwe ku-grey noma eduze kwemigodi yesilonda.Iningi lama-F3.Olig2 NSC athatha udaba olumhlophe olungashiyiwe ahlukaniswe abe ama-oligodendrocyte avuthiwe.Ukufakelwa kabusha kwe-F3.Olig2 NSCs kwenyusa ivolumu yento emhlophe elondoloziwe futhi kwanciphisa umthamo we-cavity.Ngaphezu kwalokho, izixhumi ze-F3.Olig2 zandisa kakhulu ukujiya kwe-myelin sheath ezungeze ama-axon endabeni emhlophe elondoloziwe.Okokugcina, izilwane ezine-F3.Olig2 grafts zibonise ukuthuthukiswa kwekhwalithi ye-hindlimbs locomotion.Ukudluliselwa kwe-NSCs okuguquliwe ngokwezakhi zofuzo ukuze kuhlukaniswe uhlu lwe-oligodendrocytic kungase kube isu eliphumelelayo lokuthuthukisa imiphumela yokusebenza kulandela ukuhlukumezeka komgogodla.Ucwaningo lwamanje luphakamisa ukuthi izici zamangqamuzana ezilawula izinqumo zokudalelwa kweseli zingashintshwa ukuze kuthuthukiswe amandla okubuyisela okwelashwa okusekelwe kumaseli.
