I-Glutathione oxidized Cas: 27025-41-8 White crystalline powder
| Inombolo Yekhathalogi | XD90283 |
| Igama Lomkhiqizo | I-Glutathione i-oxidized |
| I-CAS | 27025-41-8 |
| I-Molecular Formula | I-C20H32N6O12S2 |
| Isisindo samangqamuzana | 612.63 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 2930909899 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | I-crystalline powder emhlophe |
| Ukuzungezisa okuqondile | -96 kuya ku-106 |
| Izinsimbi ezinzima | 10ppm ubuningi |
| AS | 2ppm ubuningi |
| Ukulahlekelwa Ekumisweni | 15.0% ubuningi. |
| Ubumsulwa | 95% min |
| Izinsalela ekushiseni | 0.5% ubuningi |
I-Hepatotoxicity yabaqokelwe izidakamizwa ingenye yezinto ezikhathazayo ezinkulu ekuhlolweni kwezidakamizwa ekutholweni kwezidakamizwa kusenesikhathi.Ukutholwa kokucindezeleka kwe-hepatic oxidative kungaba inkomba yokuqala ye-hepatotoxicity futhi kuzuzise ukukhethwa kwezidakamizwa.I-glutathione (GSH) kanye ne-glutathione disulfide (GSSG) pair, njengenye ye-intracellular redox elawula imibhangqwana, idlala indima ebalulekile ekuvikeleni amangqamuzana ekucindezelekeni kwe-oxidative okubangelwa ukungalingani phakathi kwama-prooxidants nama-antioxidants.Ukunqunywa komthamo wezilinganiso ze-GSSG/GSH kanye nokugxila kwe-GSH ne-GSSG kusetshenziswe ukukhombisa ukucindezeleka kwe-oxidative kumaseli namathishu.Kulolu cwaningo, sihlole ukuthi kungenzeka yini ukusebenzisa izilinganiso ze-GSSG/GSH ze-biliary njenge-biomarker ukukhombisa ingcindezi ye-hepatic oxidative kanye nobuthi bezidakamizwa.Izinhlanganisela ezine ezaziwa ngokushintsha amazinga e-GSH kanye ne-GSSG zihloliwe kulolu cwaningo.I-Diquat (i-diquat dibromide monohydrate) ne-acetaminophen yanikezwa amagundane.I-Paraquat ne-tert-butyl hydroperoxide yanikezwa d kumagundane ukuze yenze izinguquko ze-GSH ye-biliary ne-GSSG.I-GSH ne-GSSG ye-biliary ziye zalinganiswa kusetshenziswa amajika okulinganisa alungiselelwe nge-bile yokwenziwa ukuze kulandiswe nganoma yimuphi umphumela we-bile matrix ekuhlaziyweni kwe-LC-MS kanye nokugwema ukugxambukela kwe-GSH engapheli kanye ne-GSSG.Ngezibonelo ezine (kumagundane namagundane) zezinguquko ezibangelwa izidakamizwa ku-kinetics yezilinganiso ze-biliary GSSG/GSH, lolu cwaningo lubonise amandla okuthuthukisa inkomba yempendulo yokuchayeka esekelwe kuzilinganiso ze-GSSG/GSH ze-biliary zokubikezela ukucindezeleka kwe-hepatic oxidative.
