I-Hoechst 33258 Cas: 23491-45-4 I-crystalline powder ephuzi ephaphathekile
Inombolo Yekhathalogi | XD90536 |
Igama Lomkhiqizo | I-Hoehst 33258 |
I-CAS | 23491-45-4 |
I-Molecular Formula | C25H24N6O·3(HCl) |
Isisindo samangqamuzana | 533.88 |
Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
Ukubukeka | Impushana ecwebezelayo ephuzi |
Isivivinyo | 99% |
Ukusebenzisana phakathi kwesidakamizwa esilwa noshukela, i-Metformin nethole le-thymus DNA (CT-DNA) ku-(50mM Tris-HCl) buffer kwacwaningwa ngokumuncwa okubonakalayo kwe-UV-Visible, i-fluorescence, i-CD spectroscopy kanye nezilinganiso ze-viscosity.Ocwaningweni lwe-fluorimetric, i-enthalpy kanye ne-entropy yokusabela phakathi kwesidakamizwa ne-CT-DNA kubonise ukuthi ukusabela ku-exothermic (ΔH=-35.4522 kJ mol(-1); ΔS=-49.9523 J mol(-1)K(-1) )).Ucwaningo olubophezela ukuncintisana lubonise ukuthi umuthi ungakhulula i-Hoechst 33258 ngokuphelele.Inkimbinkimbi ibonise ukumuncwa kwe-hyperchromism ku-spectrum yayo ye-UV-Vis ene-DNA.Ukubopha okungaguquki okubaliwe, K(b), okutholwe ezifundweni zokumuncwa kwe-UV-Vis kwaba ngu-8.3×10(4)M(-1).Ngaphezu kwalokho, izinguquko ku-spectra ye-CD phambi kwesidakamizwa zibonisa ukuzinza kohlobo lwe-B olungakwesokudla lwe-CT-DNA.Ekugcineni, izilinganiso ze-viscosity zembula ukuthi ukubophezela kwesakhiwo esine-CT-DNA kungase kubophe phezulu, ikakhulukazi ngenxa yokubophezela kwe-groove.Copyright © 2012 Elsevier BV Wonke amalungelo agodliwe.