I-L-Alanine CAS:56-41-7 99% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | XD90326 |
| Igama Lomkhiqizo | D-Alanine |
| I-CAS | 338-69-2 |
| I-Molecular Formula | C3H7NO2 |
| Isisindo samangqamuzana | 89.09 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29224985 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| Isivivinyo | 98.5 - 101.5% |
| Ukuzungezisa okuqondile | +13,7 ukuze +15,1 |
| Izinsimbi ezinzima | <0.0015% |
| pH | 5.5 - 7 |
| I-SO4 | <0.03% |
| Ukulahlekelwa Ekumisweni | <0.2% |
| Insimbi | <0.003% |
| Izinsalela ekushiseni | <0.15% |
| Usayizi Wezinhlayiyana | 200um |
| Cl | <0.05% |
| Izinga lokungcola okuphilayo okuqhubekayo | Azikho izinto ezingcolisayo |
I-γ-Glutamyltranspeptidases (γ-GTs) ihlukanisa ibhondi ye-γ-glutamyl amide ye-glutathione futhi idlulisele iqembu elikhululiwe le-γ-glutamyl emanzini (hydrolysis) noma ama-amino acid owamukelayo (transpeptidation).Lawa ma-enzyme atholakala yonke indawo adlala indima ebalulekile ekwenziweni kwe-biosynthesis kanye nokuwohloka kwe-glutathione, nasekukhipheni ubuthi be-xenobiotic.Lapha sibika ukwakheka kwekristalu kwe-3Å kwe-Bacillus licheniformis γ-GT (BlGT) kanye nalokho okuyinkimbinkimbi yayo ene-l-Glu.Izakhiwo ze-X-ray ziqinisekisa ukuthi i-BlGT ingeyomndeni omkhulu we-N-terminal nucleophilic hydrolase futhi iveza ukuthi iphrotheni inendawo evulekile evulekayo efana naleyo ebikwe i-enzyme ye-homologous evela ku-Bacillus subtilis, kodwa ehlukile kulawo aqashelwa i-γ-GT yomuntu kanye. ama-γ-GT avela kwamanye ama-microorganisms.Idatha iphakamisa ukuthi ukuboshwa kwe-l-Glu kudala ukuhleleka kabusha komsila we-C weyunithi enkulu ye-BlGT futhi kuvumela ukukhonjwa kweqoqo lezinsalela ze-asidi okungenzeka zihileleke ekubonweni kwe-ion yensimbi.Indima yalezi zinsalela ekuzinzeni kokuvumelana kwe-BlGT iye yacutshungulwa ngokufaka uphawu lokucutshungulwa ngokuzenzakalela, umsebenzi we-enzymatic, amakhemikhali kanye nokushintshashintsha kwe-thermal kwezishintshayo ezine ze-Ala eyodwa.Imiphumela ibonisa ukuthi ukushintshwa kwe-Asp568 nge-Ala kuthinta kokubili ukucubungula ngokuzenzakalela kanye nokuzinza kwesakhiwo sephrotheni.
