I-Protein Kinase Supplement KT5823 CAS:126643-37-6
| Inombolo Yekhathalogi | XD90398 |
| Igama Lomkhiqizo | I-Protein Kinase Supplement KT5823 |
| I-CAS | 126643-37-6 |
| I-Molecular Formula | I-C29H25N3O5 |
| Isisindo samangqamuzana | 495.53 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
Ama-receptors e-ATP-gated P2X3 angama-transducers abalulekile we-nociceptive stimuli futhi acishe avezwe ngokukhethekile yi-sensory ganglion neurons.Ku-mouse trigeminal ganglion (TG), umsebenzi we-P2X3 receptor uthuthukiswa ngokungalindelekile yi-pharmacological block ye-natriuretic peptide receptor-A (NPR-A), echaza indima engaba inhibitory ye-endogenous natriuretic peptide in nociception mediated by P2X3 receptors.Ukuntuleka koshintsho ekukhulumeni kwamaprotheni e-P2X3 kubonisa ukuguquguquka okuyinkimbinkimbi okunezindlela zazo zokwehlisa ukusebenza kwe-P2X3 receptor zihlala zingacacile. blocker anantin.Ngakho-ke, siphenye izinguquko ekusabalaliseni kwesamukeli se-P2X3 endaweni ye-lipid raft membrane, isimo sazo se-phosphorylation, kanye nokusebenza kwazo ngokucindezela ama-patch.Ukuqala okulibazisekayo kokungazweli kwe-P2X3 bekuyindlela eyodwa yokuthuthukisa okudalwa yi-anantin komsebenzi we-P2X3.I-Anant ekusetshenzisweni ibangele ukusabalalisa kabusha kwesamukeli se-P2X3 okukhethekile endaweni ye-lipid raft kanye nokuncipha kwe-P2X3 serine phosphorylation, izenzakalo ezimbili ebezingancikene.I-inhibitor ye-cGMP-dependent protein kinase kanye ne-siRNA-mediated knockdown ye-BNP ilingise umthelela we-anantin.Sibonise ukuthi kuma-mouse trigeminal neuron endogenous BNP isebenza kuma-NPR-A receptors ukuze kutholwe ukucindezeleka okuyisisekelo kokusebenza kwe-P2X3 receptor.Ukuvinjelwa kwe-Tonic yomsebenzi we-P2X3 ye-receptor nge-BNP/NPR-A/PKG izindlela kwenzeka ngezindlela ezimbili ezihlukene: i-P2X3 serine phosphorylation kanye nokusabalalisa kabusha kwesamukeli kumakhompathimenti angewona ama-raft.Le nqubo yenoveli yokulawula i-receptor ingase ibe inhloso yezifundo zesikhathi esizayo ezihloswe ekwehliseni umsebenzi we-P2X3 we-Dysregulated receptor ebuhlungu obungapheli.
