Imikhiqizo

Ukuphenya umthelela wamafutha e-spearmint ezinguqukweni ezifana ne-emphysema kanye nokuvezwa kwe-tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta(IL-1beta), i-matrix metalloproteinase-9 (MMP-9) kanye ne-tissue inhibitor ye-metalloproteinase. -1 (TIMP-9) ku-lipopolysaccharide (LPS) amagundane aphathwayo.Imodeli yezinguquko ze-Emphysematous yenziwa ngokufakwa kwe-intracheal ye-LPS kanye ngesonto kuze kufike kumaviki angu-8 kumagundane.Amagundane ahlukaniswe ngokulawula, i-dexamethasone (0.3 mg x kg(-1)), namafutha e-spearmint (10, 30,100 mg x kg(-1)) amaqembu.Iqembu ngalinye laliphathwa ngosawoti, i-dexamethasone, ne-spearmint yamafutha ngokulandelana kwamasonto angu-4.Kwabe sekwenziwa izibalo eziphelele nezihlukene zamangqamuzana egazi amhlophe ku-bronchoalveolar lavage fluid(BALF).Izinguquko ze-pathologic zezicubu zamaphaphu ezifana nesakhiwo se-alveolar, ukuvuvukala kwendlela yomoya, kanye ne-goblet cell metaplasia kwabonwa yi-HE ne-AB-PAS staining.Ukuvezwa kwe-TNF-alpha, IL-1beta, TIMP-1 kanye ne-MMP-9 kuye kwalinganiswa.Kokubili i-spearmint ne-dexamethasone yehlise ukubhujiswa kwe-alveolus yamaphaphu.Isibalo esiphelele nesihlukile samangqamuzana egazi amhlophe ku-BALF okuhlanganisa i-neutrophile ne-lymphocyte yamafutha e-spearmint 100 mg x kg(-1) kanye neqembu le-dexamethasone ancipha kakhulu, futhi i-goblet cell metaplasia nayo yavinjelwa.I-Dexamethasone ibe nomthelela ovimbelayo ekukhulumeni kwe-TNF-alpha, IL-1beta, TIMP-1 ne-MMP-9.Amafutha e-spearmint 30, 100 mg x kg(-1) ehlise kakhulu i-TNF-alpha ne-IL-1beta ngokulandelanayo.Amafutha e-spearmint 10, 30 kanye ne-100 mg x kg (-1) ayengenawo umthelela ekukhulumeni kwe-TIMP-1, kodwa anganciphisa inkulumo ye-MMP-9 ngokuphawulekayo ezicutshini zamaphaphu. ngoba ithuthukisa ukubhujiswa kwe-alveolar, ukuvuvukala kwamaphaphu, kanye ne-goblet cell metaplasia.Indlela yokusebenza ingase ihlanganise ukwehlisa okuqukethwe kwe-TNF-alpha, IL-1beta kanye nokuvimbela ukuveza ngokweqile kwe-matrix metalloproteinase-9 ezicutshini zamaphaphu.