I-Tetracycline hydrochloride CAS: 64-75-5 99% I-crystalline powder ephuzi
| Inombolo Yekhathalogi | XD90366 |
| Igama Lomkhiqizo | I-Tetracycline hydrochloride |
| I-CAS | 64-75-5 |
| I-Molecular Formula | I-C22H24N2O8 · I-HCl |
| Isisindo samangqamuzana | 480.90 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 29413000 |
Ukucaciswa Komkhiqizo
| Isiphetho | Ihambisana ne-BP2013, EP7, USP38 |
| Izinsimbi ezinzima | <0.005% |
| Ukungcola Okukodwa | <0.1% |
| Ukuhlonza | I-IR, UV, HPLC, TLC |
| pH | 1.8-2.8 |
| Ukulahlekelwa Ekumisweni | <2.0% |
| I-solvent eyinsalela | n-Butanol <3000ppm |
| Isivivinyo | BP2013/EP7 99% |
| Umlotha one-sulphate | <0.5% |
| Ukujikeleza okuqondile okubonakalayo | -240 kuya ku-255° |
| Amandla | USP 38: >900ug/mg |
| Ukungcola Okuphelele | <5% |
| Ukubukeka | I-crystalline powder ephuzi |
| 4-epianhydrotetracycline | <2% |
| Imikhawulo ye-Microbial | Iyahambisana |
| 4-Epiteracycline | <3% |
| I-Anhydrotetracyoline | <0.5% |
| I-Chlortetracycline Hydrochloride | <0.5% |
| I-Residual Solvent | <100ppm |
Ukuthuthukiswa kokumelana ne-antimicrobial kwabelwe ngokweqile kanye nokusetshenziswa kabi kwama-antimicrobial agents.I-Staphylococci iyingxenye yezitshalo ezivamile kodwa futhi zingamagciwane angase abe namandla ekumelana nama-antibiotic amaningi aziwayo.Ukumelana ne-coagulase negative staphylococci (CoNS) kuphakanyiswa ukuthi kuguquke ngenxa yengcindezi ekhethiwe elandela ukwelashwa ngama-antibiotic.Lolu cwaningo luphenye ukuba khona kwama-antimicrobial agents ayisishiyagalolunye asetshenziswa kakhulu emchameni womuntu ovela ezigulini ezingalaliswa ezibhedlela ezimbili eGhana maqondana nokumelana ne-CoNS.Umchamo kanye ne-CoNS kwathathwa amasampula (n = 246 kanye no-n = 96 ngokulandelanayo) ezigulini ezibhedlela ezimbili eGhana.I-CoNS ihlonzwe kusetshenziswa i-Gram staining, i-coagulase test, kanye ne-MALDI-TOF/MS, futhi ukuba sengozini kwe-antimicrobial kuma-antimicrobial angu-12 asetshenziswa ngokuvamile kwanqunywa ukusabalalisa kwediski.Ngaphezu kwalokho indlela yokuhlaziya yasungulwa ukuze kutholakale ama-ejenti alwa namagciwane ayisishiyagalolunye avame ukusetshenziswa kakhulu eGhana ngokusebenzisa i-solid-ph ase extraction ehlanganiswe ne-HPLC-MS/MS kusetshenziswa i-electron spray ionization.Imvamisa ephezulu kakhulu yokumelana ne-CoNS yabonwa nge-penicillin V (98%), i-trimethoprim (67%), ne-tetracycline (63%).I-S. haemolyticus kwakuyi-isolate evame kakhulu (75%), ilandelwa i-S. epidermidis (13%) kanye ne-S. hominis (6%).I-S. haemolyticus futhi yayiwuhlobo olubonisa ukumelana okuphezulu kakhulu (82%).I-69% ye-CoNS engayodwa yayingazweli emithini eminingi (≧ 4 ama-antibiotics) kanti ama-45% e-CoNS ayengazweli nge-methicillin.Ama-antimicrobial agents atholwe ku-64% wamasampula omchamo ahlaziywe (n = 121) lapho ama-antimicrobial avame ukutholwa kwakuyi-ciprofloxacin (30%), i-trimethoprim (27%), ne-metronidazole (17%).Okutholakele okukhulu kwalolu cwaningo kwaba ukuthi ukusabalala kwama-antimicrobial atholakele emchameni kwakuvame kakhulu kunokusetshenziswa okubikwe yiziguli kanye nokusabalala kwe-S. haemolyticus engazweli kwakuvame kakhulu kunezinye izinhlobo ze-ConS ezimelene lapho ama-antimicrobial agents etholakala emchameni.
