I-Spiramycin Cas: 8025-81-8
| Inombolo Yekhathalogi | XD90452 |
| Igama Lomkhiqizo | I-Spiramycin |
| I-CAS | 8025-81-8 |
| I-Molecular Formula | I-C43H74N2O14 |
| Isisindo samangqamuzana | 843.05 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana Emhlophe |
| Isivivinyo | > 4100IU/mg |
| Izinsimbi ezinzima | <20ppm |
| Ukulahlekelwa Ekumisweni | < 3.5% |
| Umlotha one-sulphate | < 1.0% |
| I-Ethanol | < 2.0% |
| Ukujikeleza okuqondile okubonakalayo | -85 kuya ku-80 degrees |
I-Streptomyces ambofaciens ihlanganisa i-macrolide antibiotic spiramycin.I-biosynthetic gene cluster ye-spiramycin iphawulelwe i-S. ambofaciens.Ngokungeziwe kuzakhi zofuzo ezilawulayo i-srmR (srm22), ekhonjwe ngaphambilini (M. Geistlich et al., Mol. Microbiol. 6:2019-2029, 1992), izakhi zofuzo ezintathu ezibekayo zokulawula zazikhonjwe ngokuhlaziywa kokulandelana.Ukuhlaziywa kwenkulumo yofuzo kanye nokuhlolwa kokungasebenzi kofuzo kubonise ukuthi eyodwa kuphela yalezi zakhi zofuzo ezintathu, i-srm40, edlala indima enkulu ekulawuleni i-spiramycin biosynthesis.Ukuphazamiseka kwe-srm22 noma i-srm40 kuqede ukukhiqizwa kwe-spiramycin ngenkathi ukuveza kwayo ngokweqile kukhuphula ukukhiqizwa kwe-spiramycin.Ukuhlaziywa kwenkulumo kwenziwe ngokulotshwa okuhlanekezelwe-PCR (RT-PCR) kuzo zonke izinhlobo zofuzo zeqoqo kuhlobo lohlobo lwasendle kanye naku-srm22 (srmR) kanye nezinguquko zokususwa kwe-srm40.Imiphumela evela ekuhlaziyweni kwenkulumo, kanye naleyo evela ekuhloleni kokuphelelisa, ibonise ukuthi i-Srm22 iyadingeka ekukhulumeni kwe-srm40, i-Srm40 iyisicupha sendlela ethile esilawula kakhulu, uma kungezona zonke, zofuzo lwe-spiramycin biosynthetic.
